Effects of vitamin K1 supplementation on vascular responsiveness and oxidative stress in a rat femoral osteotomy model

Abstract

The main function of vitamin K1 is to act a co-factor for gamma-glutamyl carboxylase. However, it has also been shown to lessen oxidative stress. This study was aimed to evaluate the effect of vitamin K1 supplementation on vascular responsiveness and oxidative status in rats that underwent femoral osteotomy. Twenty-four male rats were divided into three groups to serve as sham, osteotomy and vitamin K1 groups. Indices of oxidative stress (catalase), and oxidative damage (malondialdehyde) were analysed in erythrocytes. In order to evaluate vascular reactivity, concentration-response curves to phenylephrine, angiotensin II, 5-hydroxytryptamine, bradykinin and histamine were constructed. The findings of this study clearly show that oxidative stress clearly increases after femoral osteotomy in rats. Also, this operation causes a significant depression in vascular responsiveness to contracting agents and endothelium-dependent vasodilators. However, vitamin K1 supplementation prevents vascular hyporeactivity by reducing oxidative stress and may represent a novel approach during osteotomy healing.

Oxidative stability of fish oil enriched drinking yoghurt

“…Vitamins such as vitamin E and C are known for their antioxidative effects. A few studies have also reported that vitamin K may have antioxidative effects (Mukai, Morimoto, Kikuchi, & Nagaoka, 1993;Tasatargil et al, 2006), but to the best of our knowledge the ability of vitamin K to prevent oxidation in drinking yoghurt with or without oil has never been investigated. Since vitamin K is a naturally occurring lipid-soluble substance, it may be an attractive natural alternative to synthetic antioxidants.…”

The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

“…Moreover, calcium intake may aff ect oxidative stress through calcium transport and signaling line [ 41 ] . Although vitamin K is not a classical antioxidant, previous studies suggest that vitamin K1 could act as a potent antioxidant through the formation of hydroxyl radicals during the peroxidation reaction [ 42 ] .…”