Effects of vitamin E on neurodegenerative diseases: an update

İçer, Mehmet Arif; Arslan, Neslihan; Karadağ, Makbule Gezmen

doi:10.21307/ane-2021-003

Cited by 23 publications

(13 citation statements)

References 114 publications

(137 reference statements)

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“…172 Many studies have demonstrated that VE can prevent neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) can both be prevented by VE. 173,174 Mounting evidence suggests that patients with autism have low methylation ability and increased production of reactive oxygen species (ROS). In a postmortem study of brain tissues, patients with autism reported higher levels of oxidative stress biomarkers than healthy controls.…”

Section: Vitamin Ementioning

confidence: 99%

The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui,

Zhai,

Wang

et al. 2024

Food Funct.

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Section: Vitamin Ementioning

confidence: 99%

The role and impact of abnormal vitamin levels in autism spectrum disorders

Cui,

Zhai,

Wang

et al. 2024

Food Funct.

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“…Being the most abundant form of vitamin E, α-tocopherol is found in dietary sources such as vegetable oils, nuts, and seeds. Vitamin E has been shown to exert antioxidant and anti-inflammatory properties that may potentially provide protective effects against neurodegeneration [111,112]. Patients with AD have lower circulating levels of vitamin E in cerebrospinal fluid (CSF) [70] and serum [71].…”

Section: Vitamin Ementioning

confidence: 99%

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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Alzheimer’s disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.

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“…[ 94 , 95 ]. Although vitamin E is known for its antioxidative characteristics, due to its ability to scavenge the peroxyl radicals (ROO • ), thus inhibiting lipid peroxidation [ 94 , 95 , 96 ], data indicating vitamin E efficacy in neurodegenerative diseases such as AD, PD, stroke and ALS are inconclusive [ 97 , 98 ]. The results from the preclinical studies of its use for AMD prevention are also indecisive.…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma

2021

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Age-related macular degeneration (AMD) and glaucoma are ophthalmic neurodegenerative diseases responsible for irreversible vision loss in the world population. Only a few therapies can be used to slow down the progression of these diseases and there are no available treatment strategies for reversing the degeneration of the neural retina. In AMD, the pathological process causes the malfunction and damage of the retinal pigmented epithelium and photoreceptors in the macula. In glaucoma, damage of the retinal ganglion cells and their axons is observed and treatment strategies are limited to intraocular pressure lowering. Therefore, other prophylactic and/or therapeutic methods are needed. Oxidative stress is involved in the neurodegenerative process accompanying both AMD and glaucoma; therefore, the use of antioxidant agents would clearly be beneficial, which is supported by the decreased prevalence and progression of AMD in patients adherent to a diet naturally rich in antioxidants. Dietary antioxidants are easily available and their use is based on the natural route of administration. Many preclinical studies both in vitro and using animal models of retinal degeneration showed the efficacy of dietary antioxidants, which was further proved in clinical trials. Resveratrol is beneficial both in AMD and glaucoma animal models, but confirmed only among AMD patients. For AMD, carotenoids and omega-3 fatty acids were also proved to be sufficient in preventing neurodegeneration. For glaucoma, coenzyme Q10 and alpha-lipoic acid showed efficacy for decreasing retinal ganglion cell loss and inhibiting the accompanying destructive processes. Interestingly, the benefits of vitamins, especially vitamin E was not confirmed, neither in preclinical nor in clinical studies.

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Effects of vitamin E on neurodegenerative diseases: an update

Cited by 23 publications

References 114 publications

The role and impact of abnormal vitamin levels in autism spectrum disorders

The role and impact of abnormal vitamin levels in autism spectrum disorders

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Dietary Antioxidants in Age-Related Macular Degeneration and Glaucoma

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