Effects of Vitamin E and Sesamin on Hypertension and Cerebral Thrombogenesis in Stroke-Prone Spontaneously Hypertensive Rats.

Abstract

The preventive effects of sesamin, a lignan from sesame oil, and vitamin E on hypertension and thrombosis were examined using stroke-prone spontaneously hypertensive rats (SHRSP). At 5 weeks of age the animals were separated into four groups: (i) a control group; (ii) a vitamin E group, which was given a 1,000 mg alpha-tocopherol/kg diet; (iii) a sesamin group, given a 1,000 mg sesamin/kg diet; and (iv) a vitamin E plus sesamin group, given a 1,000 mg alpha-tocopherol plus 1,000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail-cuff method once weekly. A closed cranial window was created and platelet-rich thrombi were induced in vivo using a helium-neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8-OHdG were significantly suppressed in rats administrated vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (p<0.05). These results indicate that chronic ingestion of vitamin E and sesamin attenuated each of elevation in blood pressure, oxidative stress and thrombotic tendency, suggesting that these treatments might be beneficial in the prevention of hypertension and stroke.

Lipid Peroxidation and Antioxidants in Arterial Hypertension

“…Prevented the development of hypertension induced by RAS activation [50] Transiently decreased blood pressure in Ang IIhypertensive rats [49] Reduced blood pressure in high-volume hypertension in mice [269] Lacked a sustained antihypertensive effect in Ang II-induced hypertension [49] Ebselen Attenuated the blood pressure rise induced by Ang II in mice overexpressing p22phox in vascular smooth muscle and in littermate control mice [270] Failed to prevent the development of hypertension induced by the blockade of nitric oxide synthesis [256] Vitamin C Prevented the progression of hypertension induced by salt administration in SHRSP and in SHR [229,271] Attenuated salt-induced hypertension [272,273] Failed to prevent adrenocorticotropic hormone-induced hypertension [274] Vitamin E Prevented the progression of hypertension induced by salt administration in SHRSP [229] Attenuated hypertension in young SHRSP [275] Attenuated salt-induced hypertension [273] Failed to prevent adrenocorticotropic hormone-induced hypertension [274] Lipoic acid Reduced blood pressure in SHR [276] Prevented fructose-induced hypertension [277] Prevented/attenuated salt-induced hypertension [278] Prevented mineralocorticoid-induced Drug Antihypertensive effect Lack of antihypertensive effect hypertension [279] …”

Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

“…SO attenuates oxidative stress and multiple organ failure triggered by endotoxin lipopolysaccharide in rats [8] . Sesamin and sesaminol are the major phenolic constituents of SO which have been reported to possess a broad spectrum of pharmacological effects including antimutagenic [9] , antioxidant [10,11,12] ,antihypertensive [11] ,antiinflammatory [12] and antithrombotic [13] . This investigation was set to evaluate the protective effects of SO against DOX-induced cardiotoxicity in male rats and to study the mechanisms underlying these effects.…”

Development of Vegetable Based Milk from Decorticated Sesame (Sesamum Indicum)

“…Recently, much attention has been directed toward exploring the utilization of oilseeds in general [10] and sesame seed in special [11] for new food uses on the basis of their functional properties. Decorticated sesame seed can supply us with nutritious [3,6] functional [14] and healthy meals [8,12,13,18] with relatively low cost. The production of sesame-based dairy products can overcome the problems that limit consumption of soybased dairy products and other vegetable milk such as presence of anti-nutritional factors, Beany and astringent flavor low solids yield , Low dispersion stability flatulence factors [4,7,15] .…”