Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study

Jeong, Jae Yoon; Jun, Dae Won; Park, Sol Ji; Sohn, Joo Hyun; Kim, Sang Gyune; Lee, Se Whan; Jeong, Soung Won; Kim, Moon Young; Kim, Won; Shim, Jae Jun; Kim, Hyoung Su; Suk, Ki Tae; Ahn, Sang Bong

doi:10.3904/kjim.2018.273

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Esmat et al [ 94 ] reported no beneficial effect of vitamin D supplementation on SVR in HCV genotype 4 patients. In a multicenter randomized controlled trial, patients with chronic hepatitis C were randomly divided into two groups: PEG-IFN-α plus RBV and PEG-IFN-α plus RBV + vitamin D. The results showed that the vitamin D addition had no effect on SVR rates in treatment-naïve patients, regardless of the genotype [ 95 ]. A recent review showed that the effect of vitamin D on the early, rapid, and sustained virologic response in chronic hepatitis C patients is highly uncertain compared with placebo or no treatment [ 96 ].…”

Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Αγγελετοπούλου

Thomopoulos

Mouzaki

et al. 2022

IJMS

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There is consistent evidence that vitamin D deficiency is strongly associated with liver dysfunction, disease severity, and poor prognosis in patients with liver disease. Vitamin D and its receptor (VDR) contribute to the regulation of innate and adaptive immune responses. The presence of genetic variants of vitamin D- and VDR-associated genes has been associated with liver disease progression. In our recent work, we summarized the progress in understanding the molecular mechanisms involved in vitamin D–VDR signaling and discussed the functional significance of VDR signaling in specific cell populations in liver disease. The current review focuses on the complex interaction between immune and liver cells in the maintenance of liver homeostasis and the development of liver injury, the interplay of vitamin D and VDR in the development and outcome of liver disease, the role of vitamin D- and VDR-associated genetic variants in modulating the occurrence and severity of liver disease, and the therapeutic value of vitamin D supplementation in various liver diseases. The association of the vitamin D–VDR complex with liver dysfunction shows great potential for clinical application and supports its use as a prognostic index and diagnostic tool.

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Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Αγγελετοπούλου

Thomopoulos

Mouzaki

et al. 2022

IJMS

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Vitamin D supplementation for chronic liver diseases in adults

Bjelaković

Nikolova

Bjelaković

et al. 2021

Cochrane Database of Systematic Reviews

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Assessment of the influence of vitamin D level on the course of chronic hepatitis C in comorbidity with chronic pancreatitis

Derbak,

Buchok,

Ganych

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

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Background. Chronic hepatitis C (СHC) is often complicated by the presence of concomitant gastrointestinal diseases, one of which is chronic pancreatitis (CP). This has a negative impact on the clinical course of both diseases, contributes to nutrient deficiencies, in particular vitamin D, and worsens the quality of life of patients. The aim of the research was to study the features of the clinical course of CHC in comorbidity with CP and to evaluate the quality of life in patients with different levels of vitamin D in blood serum. Materials and methods. The study included 120 patients who were divided into 2 groups: group 1 — 72 patients with CHC and CP and group 2 — 48 patients with CHC. In turn, patients of group 1, depending on the enzymatic activity of the pancreas, were divided into group 1a (n = 52), which included patients with CHC and CP with exocrine insufficiency (EI), and group 1b (n = 20) — patients with CHC and CP with preserved exocrine function of the pancreas. In all patients, fecal coproscopy was performed, the level of fecal elastase (FE-1), vitamin D, viral load was determined, and the degree of fibrosis and necroinflammatory activity was evaluated using FibroTest and ActiTest. Situational anxiety was assessed according to the Spielberger-Hanin method, and quality of life using the SF-12 questionnaire. The analysis and processing of the results of the examination of patients was carried out using the computer program Jamovi 2.3.2.1, Microsoft Office Excel for Windows 2016 using the Kruskal-Wallis method, the Mann-Whitney-Wilcoxon criterion and the Pearson correlation coefficient. The difference was considered to be statistically significant at p < 0.05. Results. A significantly lower level of vitamin D was found in patients of group 1a than in patients of groups 1b and 2. Patients of group 1 with higher stages of fibrosis (F2–3 and F3–4), a higher degree of necroinflammatory activity in the liver (> A2) and a high viral load have lower levels of vitamin D than those with initial stages of fibrosis and less severe necroinflammatory process in the liver. Patients with CHC, CP and exocrine insufficiency complained of mood changes, increased anxiety, rapid fatigue, and muscle weakness significantly more often than those with preserved exocrine function and patients with CHC. The level of vitamin D in people with CHC, CP and exocrine insufficiency positively correlates with the level of FE-1. In all patients with CHC in comorbidity with CP, a negative effect of low levels of vitamin D on indicators of quality of life and anxiety was found. Conclusions. A reduced level of vitamin D in the blood of patients with CHC and CP worsens the course of the disease and is associated with a decrease in quality of life.

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Effects of vitamin D supplements in patients with chronic hepatitis C: a randomized, multi-center, open label study

Cited by 3 publications

References 38 publications

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Vitamin D supplementation for chronic liver diseases in adults

Assessment of the influence of vitamin D level on the course of chronic hepatitis C in comorbidity with chronic pancreatitis

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