Vitamin D supplementation for chronic liver diseases in adults

Bjelaković, Marija; Nikolova, Dimitrinka; Bjelaković, Goran; Gluud, Christian

doi:10.1002/14651858.cd011564.pub3

Cited by 24 publications

(18 citation statements)

References 210 publications

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“…A vitamin D deficit was also a predictor of overall mortality and hepatic decompensation in ACLD patients [ 109 ]. Based on all this evidence, however, a recent Cochrane meta-analysis by Bjiealovich et al concluded that there is a lack of evidence to demonstrate the efficacy of vitamin D supplementation in reducing the causes of mortality and morbidity of ACLD and that the overall quality of evidence is very low [ 110 ].…”

Section: Vitamin D In Advanced Chronic Liver Disease (Acld) and Compl...mentioning

confidence: 99%

Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease

Ravaioli

Pivetti

Marco

et al. 2022

IJMS

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Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.

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Section: Vitamin D In Advanced Chronic Liver Disease (Acld) and Compl...mentioning

confidence: 99%

Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease

Ravaioli

Pivetti

Marco

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…In a multicenter randomized controlled trial, patients with chronic hepatitis C were randomly divided into two groups: PEG-IFN-α plus RBV and PEG-IFN-α plus RBV + vitamin D. The results showed that the vitamin D addition had no effect on SVR rates in treatment-naïve patients, regardless of the genotype [ 95 ]. A recent review showed that the effect of vitamin D on the early, rapid, and sustained virologic response in chronic hepatitis C patients is highly uncertain compared with placebo or no treatment [ 96 ].…”

Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Αγγελετοπούλου

Thomopoulos

Mouzaki

et al. 2022

IJMS

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There is consistent evidence that vitamin D deficiency is strongly associated with liver dysfunction, disease severity, and poor prognosis in patients with liver disease. Vitamin D and its receptor (VDR) contribute to the regulation of innate and adaptive immune responses. The presence of genetic variants of vitamin D- and VDR-associated genes has been associated with liver disease progression. In our recent work, we summarized the progress in understanding the molecular mechanisms involved in vitamin D–VDR signaling and discussed the functional significance of VDR signaling in specific cell populations in liver disease. The current review focuses on the complex interaction between immune and liver cells in the maintenance of liver homeostasis and the development of liver injury, the interplay of vitamin D and VDR in the development and outcome of liver disease, the role of vitamin D- and VDR-associated genetic variants in modulating the occurrence and severity of liver disease, and the therapeutic value of vitamin D supplementation in various liver diseases. The association of the vitamin D–VDR complex with liver dysfunction shows great potential for clinical application and supports its use as a prognostic index and diagnostic tool.

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“…There were also no data on healthrelated quality of life. 131 Currently, nutritional interventions and exercise therapy are underutilized as effective means of prolonging life in cirrhosis (Table 4). As per the recent Japanese Society of Hepatology guidelines in an Asian population, 31 energy intake is recommended as 25-35 kcal/kg (standard body weight)/day in the absence of glucose intolerance, and protein requirements should be 1.0-1.5 g/kg/day (including BCAA preparations) in the absence of protein intolerance.…”

Section: Transplantation In Cirrhosismentioning

confidence: 99%