Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels — Results from a randomized trial

Wamberg, Louise; Kampmann, Ulla; Stødkilde-Jørgensen, Hans; Rejnmark, Lars; Pedersen, Steen B.; Richelsen, Bjørn

doi:10.1016/j.ejim.2013.03.005

Cited by 187 publications

(171 citation statements)

References 36 publications

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“…While inconsistent, Wamberg et al reported that women taking vitamin D (7,000 IU per day over 26 weeks) showed no significant changes in subcutaneous fat mass and visceral fat mass [70]. Generally, the research results show that aerobic exercise training and adequate intake of vitamin D positively affect the body weight, visceral fat and plasma lipid profiles during menopause and also reduce metabolic syndrome risk factors [70,71].…”

Section: Discussionmentioning

confidence: 83%

“…In this regard, Bacchi et al reported that for middle-aged men and women with diabetes conducting aerobic exercise using a tread mill or cycle at 60-65% of HRR, 60 minutes per day, 3 times per week for 16 weeks, the abdominal visceral fat area and subcutaneous fat area were significantly reduced [69]. While inconsistent, Wamberg et al reported that women taking vitamin D (7,000 IU per day over 26 weeks) showed no significant changes in subcutaneous fat mass and visceral fat mass [70]. Generally, the research results show that aerobic exercise training and adequate intake of vitamin D positively affect the body weight, visceral fat and plasma lipid profiles during menopause and also reduce metabolic syndrome risk factors [70,71].…”

Section: Discussionmentioning

confidence: 97%

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The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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Parvin Babaei, Arsalan Damirchi and Rastegar Hoseini. The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats. Vol. 19, No. 3, pp.173-182, 2015 [Purpose] The purpose of this study was to determine the interaction effects of aerobic exercise training and vitamin D supplementation on indices of obesity and plasma lipid profiles in ovariectomized (OVX) rats.[Methods] Forty female Wistar rats were divided into 5 groups: aerobic training (3 days/week for 8 weeks; AT; n = 8), aerobic training and vitamin D supplementation (OVX + AT + Vit D; n = 8), vitamin D supplementation (OVX + Vit D; n = 8), ovariectomized control (OVX + C, n = 8) and SHAM (n = 8). After blood sampling, visceral fat was taken from the abdominal cavity and weighed immediately. Data was statistically analyzed by One-way ANOVA and Repeated measure ANOVA tests with a 0.05 significance level.[Results] Body weight, visceral fat, BMI and food intake decreased significantly in OVX + AT + Vit D (P < 0.001); whereas these variables increased significantly in OVX + C (P < 0.001) and SHAM (P < 0.023) groups. At the end of two-months of follow-up, we observed significant differences in TC, TG, HDL-C, LDL-C, glucose, insulin, and HOMA-IR in all groups.[Conclusion] It seems that aerobic training with vitamin D, due to the involvement of muscle mass and exposure to dynamic pressure on the bones and muscles, increased energy expenditure, stimulated insulin exudation and glucose homeostasis, decreased insulin resistance and improved the lipid profile in ovariectomized rats.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 97%

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Babaei

Damirchi

Hoseini

2015

J. Exerc. Nutr, Biochem.

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“…Another study [33] in obese participants, did not find significant improvement in the inflammatory markers measured (Table 1).…”

Section: Studies In Overweight/obese Participantsmentioning

confidence: 99%

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Agbalalah

Hughes

Freeborn

et al. 2017

The Journal of Steroid Biochemistry and Molecular Biology

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Highlights• Vitamin D deficiency has been identified as a potential risk factor for cardiovascular disease.• Review of RCTs of effects of vitamin D supplementation on endothelial function/inflammation.• 8/29 studies reported improvements in the endothelial/inflammatory parameters measured.• This review does not support use of vitamin D as a preventative measure for CVD. AbstractThis systematic review aims to evaluate randomised controlled trials (

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“…Intervention studies have been designed to study the causality between low plasma 25(OH)D levels and obesity. Except for Salehpour et al (112) who reported that VD supplementation decreased body fat mass in healthy overweight and obese women, most randomised clinical trials have failed to demonstrate any benefit of VD supplementation in terms of weight loss (113)(114)(115) . These data were recently meta-analysed, and the lack of major effect of VD supplementation on weight loss was confirmed (116) .…”

Section: Effects Of Vitamin D On Obesity and Associated Disorders In mentioning

confidence: 99%

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

et al. 2015

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Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD-obesity relationship.Adipose tissue: Vitamin D: Obesity: Inflammation: Adipocytes: Nutrients: Nutrition Vitamin D: a brief overview Vitamin D (VD; calciferol) is a hormone mainly described for its role as a regulator of phosphate and calcium homeostasis (1) . It can be obtained through animal (VD 3 , cholecalciferol) or plant (VD 2 , ergocalciferol) food sources. Only a few foodstuffs contain significant amounts of VD, the main sources being fish liver oils, fatty fish (sardines, herring and mackerel) and egg yolk (2,3) , but small quantities are also found in fortified milk, orange juice, bread and cereals. Alternatively, VD 3 is produced endogenously in the skin after UVB irradiation from the precursor 7-dehydrocholesterol to give pre-VD 3 , which is further isomerised to VD 3 before being released into the circulation (4) . Classical estimates have assigned a majority (70-90 %) of VD supply to dermal synthesis, but a recent paper revised this figure down to just 10-25 % of VD supply (5) and posited that dietary intake of 25-hydroxy-vitamin D (25(OH)D) is a significant contributor to total VD input.Adipose tissue is a major storage site for vitamin D Despite limited data, it is widely accepted that adipose tissue is a reservoir for VD in human subjects and rats (6)(7)(8)(9)(10) . Interestingly, visceral fat was found to contain 20 % more VD than subcutaneous fat (11) . Heaney et al. (12) calculated that 65 % of total VD in the body is in the form of D 3 , for which adipose tissue and skeletal muscle appear to be the main body stores (accounting for 73 and 16 %, respectively).

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Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels — Results from a randomized trial

Cited by 187 publications

References 36 publications

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Vitamin D modulates adipose tissue biology: possible consequences for obesity?

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