Effects of Vitamin D supplementation on physical activity of patients with Heart Failure

Abstract

Objective:To see the role of Vitamin D supplementation on physical status of patients suffering from Congestive Heart Failure (dilated cardiomyopathy).Methods:In this nonrandomized clinical trial, Forty three Patients with dilated cardiomyopathy who were not showing any significant improvements in physical performance on optimal treatment of heart failure were included. Vitamin D (200,000 IU) supplementation on weekly basis for a period of 12 weeks was added to heart failure treatment. And its effect was seen on 6 minutes’ walk distance and Pro-BNP levels. SPSS version 19 was used for data analysis. Dependent sample t-test was used to see the significant effect of vitamin D supplementation on pre- intervention vitamin D levels, 6MWD and Pro-BNP. Taking p-value <0.05 as significant.Results:On clinical assessment most of the patients were in NYHA class II (65%), the percentages of NYHA Class I, III and IV was 19%, 9% and 7% respectively. The baseline mean vitamin D level of the study group was 16.59±3.54ng/ml and it raised to 31.97±3.64ng/ml after 12 weeks of supplementation with vitamin D, p value<0.0005. The mean distance travelled by the study group before the intervention was 806±380ft while it increased to 945±393ft after the intervention, p value of 0.008. The mean of pro-BNP level of the study group before the intervention was 1024±635 while it improved to 159±80 after the intervention with a significant p value<0.0005.Conclusion:Vitamin D supplementation decreases the severity of HF as reflected by reduction in serum pro-BNP levels and significant increase in six minutes’ walk distance.

Vitamin D3 repletion versus placebo as adjunctive treatment of heart failure patient quality of life and hormonal indices: a randomized, double-blind, placebo-controlled trial

“…Our study is the first to provide vitamin D3 at a dose shown to replenish vitamin D stores, and also measure QOL. Prior research demonstrates that improvement in QOL predicts event-free survival in heart failure patients [ 30 ]. Comparatively, current treatments don’t approach the effect size for QOL that our study has shown.…”

The Effect of Giving Vitamin D Supplements on Improving Ejection Fraction in Heart Failure Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

“…The influencing mechanism is the role of vitamin D as an inflammation modulator and regulation system renin-angiotensin-aldosterone (RAAS), which inhibits the production of parathyroid hormone (PTH), thereby causing left ventricular hypertrophy, causing hypocalcemia, which induces hypertrophy in cardiac myocytes and can reduce cardiac contractility. [6][7][8][9][10] This study aimed to determine the effect of giving vitamin D supplements on improving ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital (RSMH), Palembang, Indonesia.…”

Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

“…Vitamin supplementations have already been part of treatments of specific diseases for many years [ 11 , 12 ] and have also been tested in the frame of HF with variable degrees of success [ 13 ]. However, conflicting results from a series of small clinical studies [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ] only showed that more research is needed to better define which type of vitamin supplementation protocol should be implemented and which HF etiologies and stages of the syndrome should selectively be targeted by these potential treatments. To face the profound metabolic disorders described in HF, the big family of B vitamins are emerging as promising supplements to manage HF for two main reasons; first, B vitamins are highly involved in numerous elementary processes of cardiac energy metabolism [ 21 ] and second, B vitamins are deficient in HF patients due to the use of diuretics, malnutrition, and advanced age [ 22 , 23 ].…”