Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial

Jafari, Tina; Faghihimani, Elham; Feizi, Awat; Iraj, Bijan; Javanmard, Shaghayegh Haghjooy; Esmaillzadeh, Ahmad; Fallah, Aziz A.; Askari, Gholamreza

doi:10.1016/j.clnu.2015.02.014

Cited by 84 publications

(85 citation statements)

References 29 publications

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“…Of the 23 studies that were included in the systematic review, 13 reported fasting glucose as primary or secondary outcome measure (19,20,21,22,23,24,26,27,28,32,35,36,39). Three studies reported a significant reduction in fasting glucose level after vitamin D supplementation (21,28,39).…”

Section: The Effect On Fasting Glucosementioning

confidence: 99%

“…Three studies reported a significant reduction in fasting glucose level after vitamin D supplementation (21,28,39).…”

Section: The Effect On Fasting Glucosementioning

confidence: 99%

“…Thirteen studies reported data on insulin resistance, of which twelve studies used the HOMA-IR to quantify insulin resistance (19,20,21,22,24,25,26,29,30,35,36,39), and one study measured insulin resistance through hyperinsulinaemic-euglycaemic clamp method (23). Two studies observed a significant reduction in insulin resistance after vitamin D supplementation (21,39), and one study found a negative effect of vitamin D supplementation on insulin resistance compared with placebo (35).…”

Section: The Effect On Insulin Resistancementioning

confidence: 99%

“…The quality assessment of the studies resulted in 14 out of 23 studies having a good quality (Appendix 1, see section on Appendix given at the end of this article) (12,19,20,21,22,23,24,25,26,27,28,29,30,31). The main characteristics and main outcomes of the included studies are given in Table 1.…”

Section: Description Of the Studiesmentioning

confidence: 99%

“…All studies had a randomized controlled trial design, of which 18 studies used a placebo for control (12,19,20,22,23,24,25,27,29,30,31,32,33,34,35,36,37,38), three studies compared vitamin D fortified yoghurt versus plain yoghurt (21,28,39), one study used oral calcium supplementation for control (26), and one study used vitamin C supplementation for control (40). Apart from two studies, which solely included post-menopausal women (21,33), all studies included both men and women. Mean age varied from 44 to 67 years (24,25 Favours control Favours vitamin D Figure 3 Mean change from baseline in serum 25(OH)D (nmol/L) between intervention and control.…”

Section: Description Of the Studiesmentioning

confidence: 99%

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MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Krul-Poel

Wee

Lips

et al. 2017

European Journal of Endocrinology

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Objective: Epidemiologic studies suggest that vitamin D status plays a role in glycaemic control in patients with type 2 diabetes. However, intervention studies yielded inconsistent results. The aim of this study is to systematically review the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. Methods: Systematic review and meta-analysis. We searched Medline, Embase and the Cochrane Library for RCTs examining the effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes. A random-effects model meta-analysis was performed to obtain a summarized outcome of vitamin D supplementation on HbA 1c , fasting glucose and homeostasis model assessment -insulin resistance (HOMA-IR). Results: Twenty-three RCTs were included in this systematic review representing a total of 1797 patients with type 2 diabetes. Mean (± s.d.) change in serum 25-hydroxyvitamin D varied from 1.8 ± 10.2 nmol/L to 80.1 ± 54.0 nmol/L. Nineteen studies included HbA 1c as outcome variable. Combining these studies no significant effect in change of HbA 1c was seen after vitamin D intervention compared with placebo. A significant effect of vitamin D supplementation was seen on fasting glucose in a subgroup of studies (n = 4) with a mean baseline HbA 1c ≥ 8% (64 mmol/mol) (standardized difference in means: 0.36; 95% CI: 0.12-0.61, P = 0.003). Conclusions: Current evidence of RCTs does not support short-term vitamin D supplementation in a heterogeneous population with type 2 diabetes. However, in patients with poorly controlled diabetes, a favourable effect of vitamin D is seen on fasting glucose.

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Section: The Effect On Fasting Glucosementioning

confidence: 99%

“…Three studies reported a significant reduction in fasting glucose level after vitamin D supplementation (21,28,39).…”

Section: The Effect On Fasting Glucosementioning

confidence: 99%

Section: The Effect On Insulin Resistancementioning

confidence: 99%

Section: Description Of the Studiesmentioning

confidence: 99%

Section: Description Of the Studiesmentioning

confidence: 99%

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MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Krul-Poel

Wee

Lips

et al. 2017

European Journal of Endocrinology

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Food Metabolism and Chronic Diseases

Tiwari,

Yadav,

Hamsa

et al. 2023

Nutritional Science and Technology

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A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices

et al. 2020

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Some reports indicated that Vitamin D may improve glycaemia indices in diabetic patients. The aim of this systematic and meta‐analysis was to evaluate effects of Vitamin D fortification on indices of glycemic control. Six databases (PubMed/Medline, ISI Web of Knowledge, Cochrane Library, Science Direct, Scopus, and Google Scholar) were searched, for randomized controlled trials that were published up to September 2018 and that compared the effect of Vitamin D‐fortified food versus regular diet in relation to glycemic control. Of the 4,379 studies originally found, 11 articles remained to be assessed for meta‐analysis. Vitamin D fortification was associated with a significant improvement in fasting serum glucose (mean difference [MD]: −2.772; 95% confidence interval [CI]: −5.435 to −0.109) and fasting serum insulin (MD: −2.937; 95% CI: −4.695 to −1.178) in patients with Type 2 diabetes mellitus. A diet with food enriched with Vitamin D was associated with a significant improvement in homeostatic model assessment of insulin resistance (MD: −1.608; 95% CI: −3.138 to −0.079) but was not associated with a significant reduction in hemoglobin A1C (MD: 0.034; 95% CI: −0.655 to 0.069). This meta‐analysis indicates that Vitamin D fortification improves indices of glycemic control. Hence, food fortified with Vitamin D may be of potential therapeutic value in diabetic patients, as an adjuvant therapy.

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Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial

Cited by 84 publications

References 29 publications

MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

MANAGEMENT OF ENDOCRINE DISEASE: The effect of vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Food Metabolism and Chronic Diseases

A systematic review and meta‐analysis of the effect of Vitamin D‐fortified food on glycemic indices

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