Effects of vitamin D deficiency and combination antiretroviral therapy on bone in HIV-positive patients

Childs, Kathryn; Welz, Tanya; Samarawickrama, Amanda; Post, Frank A.

doi:10.1097/qad.0b013e32834f324b

Cited by 52 publications

(45 citation statements)

References 72 publications

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“…There could be increased catabolism of vitamin D in this study, as increased intake of the antiretroviral drug Efavirenz (EFV), has been reported by Childs et al, [68] …”

Section: Discussionmentioning

confidence: 77%

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Agbalalah

Hughes

Freeborn

et al. 2017

The Journal of Steroid Biochemistry and Molecular Biology

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Highlights• Vitamin D deficiency has been identified as a potential risk factor for cardiovascular disease.• Review of RCTs of effects of vitamin D supplementation on endothelial function/inflammation.• 8/29 studies reported improvements in the endothelial/inflammatory parameters measured.• This review does not support use of vitamin D as a preventative measure for CVD. AbstractThis systematic review aims to evaluate randomised controlled trials (

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“…There could be increased catabolism of vitamin D in this study, as increased intake of the antiretroviral drug Efavirenz (EFV), has been reported by Childs et al, [68] …”

Section: Discussionmentioning

confidence: 77%

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Agbalalah

Hughes

Freeborn

et al. 2017

The Journal of Steroid Biochemistry and Molecular Biology

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“…These findings are important in the context of Option B+, which provides lifelong antiretroviral therapy to pregnant and/or lactating women as soon as HIV is diagnosed, regardless of their baseline CD4 count, as recommended by the WHO (34,35). Although Option B+ aids considerably in the Prevention of Mother-to-Child Transmission program in resource-limited countries with a high prevalence of HIV, it has been shown that micronutrients such as vitamin D and B-12 can be negatively affected by antiretrovirals based on lower plasma concentrations (36)(37)(38). These observations call attention to the need to measure effects of Option B+ on maternal and infant vitamin status.…”

Section: Discussionmentioning

confidence: 99%

Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins

Allen

Hampel

Shahab‐Ferdows

et al. 2015

The American Journal of Clinical Nutrition

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Background: Little information is available on B vitamin concentrations in human milk or on how they are affected by maternal B vitamin deficiencies, antiretroviral therapy, or maternal supplementation. Objective: The objective was to evaluate the effects of antiretroviral therapy and/or lipid-based nutrient supplements (LNSs) on B vitamin concentrations in breast milk from HIV-infected women in Malawi. Design: Breast milk was collected from 537 women recruited within the Breastfeeding, Antiretrovirals, and Nutrition study at 2 or 6 wk and 24 wk postpartum. Women were assigned to receive antiretrovirals and LNSs, antiretrovirals only, LNSs only, or a control. Antiretrovirals and LNSs were given to the mothers from weeks 0 to 28. The antiretrovirals were zidovudine/lamivudine and nelfinavir or lopinavir/ritonavir. LNSs provided 93-118% of the Recommended Dietary Allowances of thiamin, riboflavin, niacin, pyridoxine, and vitamin B-12. Infants were exclusively breastfed. Results: LNSs increased milk concentrations of all vitamins except thiamin, whereas antiretrovirals lowered concentrations of nicotinamide, pyridoxal, and vitamin B-12. Although antiretrovirals alone had no significant effect on riboflavin concentrations, they negatively affected the LNS-induced increase in this vitamin. Thiamin was not influenced by the study interventions. Concentrations of all B vitamins were much lower than usually accepted values. Conclusions: All B vitamins were low in milk, and all but thiamin were increased by maternal supplementation with LNSs. Antiretrovirals alone decreased concentrations of some B vitamins in milk. When LNS was given in addition to antiretrovirals, the negative effect of antiretrovirals offset the positive effect of LNSs for all vitamins except thiamin. This trial was registered at clinicaltrials.gov as NCT00164762.

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“…In a recent systematic review, Childs et al [37] estimated the vitamin D deficiency prevalence in the population with HIV to be between 23% and 73%. In this review, factors that linked HIV infection and vitamin D deficiency were former drug use, a longer time from diagnoses, CD4 below 200 cells/µL, highly active antiretroviral therapy (HAART), and efavirenz use.…”

Section: Prevalence Of Vitamin D Deficiency and Insufficiency In Hiv mentioning

confidence: 98%

Vitamin D and HIV Infection

Jiménez

Lázaro

Aparicio

et al. 2015

Health of HIV Infected People

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Effects of vitamin D deficiency and combination antiretroviral therapy on bone in HIV-positive patients

Abstract: The benefits of vitamin D supplementation in this population need to be demonstrated before widespread 'test and treat' policies can be recommended as part of routine clinical practice.

Cited by 52 publications

References 72 publications

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Impact of vitamin D supplementation on endothelial and inflammatory markers in adults: A systematic review

Antiretroviral therapy provided to HIV-infected Malawian women in a randomized trial diminishes the positive effects of lipid-based nutrient supplements on breast-milk B vitamins

Vitamin D and HIV Infection

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