Effects of Visfatin Gene Polymorphism RS4730153 on Exercise-induced Weight Loss of Obese Children and Adolescents of Han Chinese

Abstract

Visfatin is a recently discovered adipokine that contributes to glucose and obesity-related conditions. This study investigates Visfatin RS4730153 polymorphism from the perspectives of its relations with glucose/lipid metabolism and its influence on the effects of exercise-induced weight loss. Eighty-eight obese Han Chinese children and adolescents were randomly selected from a 2008 Shanghai Weight Loss Summer Camp and were supervised to complete a 4 week aerobic exercise training program. Significant differences were observed in before-exercise TG value and exercise-induced HOMA-β change, with the AG group having a much higher TG value than the GG group (P ≤ 0.05), and the latter exhibiting a significantly larger before-and-after exercise HOMA-β change than the former (P ≤ 0.05). However, no significant difference was observed between the two groups in before exercise indices of body shape, function and quality, nor in exercise-induced changes of body shape, function, and quality. Findings suggest that Visfatin RS4730153 homozygous GG genotype may effect adjustment of glucose and lipid metabolism in obese children and adolescents by reducing TG levels and increasing insulin sensitivity to exercise.

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

“…Another recent non-RCT suggests that regular exercise has positive effects on obesity in Korean children by improving glycemic control and reducing body weight, thereby lowering visfatin levels (from 247.72±14.95 to 184.22±7.75; P <0.05). 60 Congruent with these findings, Lai et al 64 reported that a substantial decrease in HOMA-IR after exercise, might indicate that visfatin rs4730153 GG genotype (polymorphism), could possibly improve glucose metabolism in obese children and adolescents by enhancing insulin sensitivity to exercise. Due to the limited number of studies, ultimately, we did not conduct the meta-analysis on this hormone.…”

Chi Square Test Correlation of Physical Activity of Obese Children of Three Libyan Cities

“…The etiology of obesity seems to be associated with several factors, such as genetic polymorphisms (Lai et al, 2013;Boström et al, 2012), dysfunction of the hypothalamic hormone signaling related to satiety, appetite and hunger (Arruda et al, 2011;Thaler et al, 2010), increased release of proinfl ammatory adipokines by white adipose tissue, and positive energy balance, in which the high total calorie intake, mainly high intake of energy-dense foods rich in saturated fats (Borg et al, 2012), sugar and salt exceeds daily calorie requirement (Drewnowski et al, 2012).…”

Relação de polimorfismos nos genes da perilipina 1, visfatina, resistina e grelina com a resposta a um programa de orientação nutricional para a redução de peso corporal

“…O polimorfismo rs3801266 no gene da visfatina (NAMPT) foi relacionado com a adiposidade (IMC, circunferência abdominal e de quadril aumentados) em crianças indianas (Tabassum et al, 2012). Além disso, o genótipo GG da variante NAMPT rs4730153 foi associado com redução da trigliceridemia e aumento da sensibilidade à Insulina, em resposta ao exercício, em crianças obesas e adolescentes chinesas (Lai et al, 2013).…”

“…Em outro estudo, o genótipo GG do polimorfismo NAMPT rs4730153 foi associado com redução de triglicérides e de glicemia e aumento da sensibilidade à insulina, em crianças e adolescentes obesos, em reposta a atividade física (Lai et al, 2013). Por outro lado, os polimorfismos do NAMPT (rs78411774 A>C, rs71564769 A>C e rs2302559 A>G) não foram relacionados a paramêtros antropométricos e de consumo de uma dieta natural em obesos (Stastny et al, 2013).…”