“…While VR qualitatively helps in pain management, there is minimal consensus on its efficacy. Key benefits of VR therapy cited include the following: a) VR therapy reduces acute pain (Mallari et al, 2019 andChuan et al, 2020), (b) Its use in perioperative period could effectively relieve postoperative pain (Ding, et al, 2020 andGeorgescu et al, 2019), c) VR distraction providing immersive environments wherein patients interact with the virtual scenario appear most effective (Eijlers et al, 2019 andChuan et al, 2020), and d) VR use is effective for short-term pain relief in both acute and chronic pain (Pourmand et al, 2018 andLuo, 2019). These studies also cited serious limitations, which broadly fall under following themes: 1) Lack of systematic protocols in VR intervention, 2) Significant heterogeneity in study populations, pain conditions, and pain reporting mechanisms used in those underlying studies, 3) Limited number of studies for overcoming biases, and 4)…”