Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study

Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine

“…also Medina, 2010). In an early PET study with FDG we have shown that vinpocetine, administered in pharmacological doses, increases the regional cerebral glucose uptake and, to a certain extent, glucose metabolism in the so called peri-stroke region as well as in the intact brain tissue (Szakáll et al, 1998;Gulyás et al, 1998;Szilágyi et al, 2005). A two week long treatment increased the regional cerebral blood flow especially in the thalamus, basal ganglia and visual cortex of the non-symptomatic hemisphere .…”

Vinpocetine modulates metabolic activity and function during retinal ischemia

“…We hypothesized that the effects of vinpocetine on retinal metabolism may involve glucose, as vinpocetine increases glucose levels in ischemic brain tissue (28,55,62). We found no difference in glucose concentration between saline-treated control eyes and saline-treated eyes exposed to ischemiareperfusion (P ϭ 0.2, by Student's t-test; Fig.…”

“…In the brain, vinpocetine improves memory and cognitive function and protects against seizures and Alzheimer's disease (9,21,27,31,78). In peripheral tissues, vinpocetine is linked to regulation of blood circulation, prevention of stroke and atherosclerosis, and reduction of inflammation (6,10,22,28,61,62,79). In the eye, vinpocetine provides neuroprotection against macular degeneration, diabetic retinopathy, and visual impairment secondary to Meniere's disease (4,5,37,52,63,65).…”

“…Indeed, vinpocetine increases glucose, ATP, and phosphocreatine availability in the normal brain and cortical neurons and astrocytes affected by hypoxia or ischemia (9,25,32,40,55,62,65). Metabolic actions are likely to be most significant in ischemia of the retina because of the high energy consumption of retinal neurons.…”

Cerebral neurological complications in patients with thermal injury

“…N 1 ет поддержанию адекватного церебрального метаболизма и интегративной деятельности нервной системы. Исходя из того, что избыточ ное накопление ионов Са 2+ способствует фор мированию ряда кальцийопосредованных па тохимических процессов, свою роль в лечении церебральных осложнений играют блокаторы кальциевых каналов, такие как циннаризин, винпоцетин, нимодипин [36,40]. Также оправ данным является назначение препаратов, об ладающих антиоксидантным свойством.…”