Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits

Lee, E.A.; Kim, J.M.; lim, kyu sang; Ryu, Youn-Chul; Jeon, Woo-Min; Hong, Kyung Pyo

doi:10.1016/j.meatsci.2012.03.018

Cited by 36 publications

(17 citation statements)

References 35 publications

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“…Pork production and consumption play important roles in the development of the economy (de Almeida and Bendixen, 2012). Recently, improvement in meat quality has become one of the most important porcine breeding goals (Lee et al, 2012). JAZF1, also known as TIP27, which encodes a transcriptional repressor of NR2C2 (Nakajima et al, 2004), is involved in regulating the metabolism of growth and affects variation in human height (Johansson et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Yang¹,

He²,

Xu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.A recent study indicated that the JAZF1 gene was related to lipid metabolism by regulating the level of gene expression in humans and mice. In order to investigate whether JAZF1 gene expression was associated with fat deposition in pig, we cloned the full-coding region of the JAZF1 gene (GenBank accession No. KF307636) from porcine longissimus dorsi. Results showed that the open reading frame of JAZF1 covered 732 bp and encoded 243 amino acids. Multiple alignment of isoform sequences revealed that the deduced amino acid sequence of JAZF1 had a high degree of sequence similarity to other vertebrates, indicating that it was highly conserved during evolution. Bioinformatic analysis indicated that pig JAZF1 contained 23 phosphorylation sites and 19 glycosyl sites. JAZF1 was predicted to have 3 ZnF-C 2 H 2 and 2 low-complexity domains. The JAZF1 mRNA expression pattern indicated that JAZF1 mRNA expression level in the liver was significantly different in 2 divergent breeds (P < 0.05). This article perhaps provided an important experimental basis for further research on the mechanisms of lipid metabolism and fat deposition in pigs.

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Section: Discussionmentioning

confidence: 99%

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Yang¹,

He²,

Xu³

et al. 2015

Genet. Mol. Res.

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“…Associations between SNPs in MyoD1 and meat quality traits have been described in livestock, particularly, in pigs (Liu et al, 2008;Han et al, 2012;Lee et al, 2012). To our best knowledge, however, few studies have reported on the relationship between MyoD1 polymorphisms and poultry meat quality traits.…”

Section: Introductionmentioning

confidence: 99%

Association of <i>MyoD1</i> Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (<i>Columba livia</i>)

et al. 2019

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Myogenic differentiation 1 (MyoD1) belongs to the MyoD family and plays a key role in myogenesis and consequently, in determining muscle fiber characteristics. In this study, single nucleotide polymorphisms (SNPs) in the exons of MyoD1 were identified in 200 domestic pigeons (Columba livia) by direct DNA sequencing, and the association between MyoD1 polymorphisms and meat quality traits was analyzed. We found four novel variations (A2967G, G3044A, A3164C, and C3311G) in exon 3. The SNP A2967G is a synonymous mutation, while the other 3 SNPs are located in the 3′untranslated region. The analysis revealed 3 genotypes, in which allele A was the predominant allele in the SNP A2967G, while allele B was the predominant allele in the SNPs G3044A and A3164C. The mutations A2967G and G3044A were significantly associated with meat quality traits in pigeon. Pigeons with AA or AB genotypes had higher breast muscle concentrations of inosinic acid and intramuscular fat than those of BB genotype. Moreover, these 2 SNPs had significant effects on MyoD1 mRNA expression. The SNPs A2967G and G3044A were organized into 4 haplotypes, which formed 7 diplotypes. Association analysis showed that the diplotypes were not significantly associated with meat quality traits. Our results implied that associations do exist between MyoD1 gene polymorphisms and meat quality traits in domestic pigeons, and the AA and AB genotypes could be applied as genetic markers in marker-aid pigeon breeding.

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“…They further discovered (in accordance with our results), that animals carrying the AB genotype of the MYOG gene showed the smallest muscle fibre cut area and diameter. Regarding the influence of the MYOD1 gene, Lee et al (2012) concluded that individual genotypes have a significant effect on different types of muscle fibre characteristics. It was demonstrated, in accordance with Klosowska et al (2004), that the CC genotype in type IIB is associated with higher number of muscle fibres with a smaller area and diameter.…”

Section: Discussionmentioning

confidence: 99%

Histological characteristics of the musculus longissimus lumborum et thoracis muscle fibres in pigs in relation to selected RYR1, MYOG, MYOD1 and MYF6 genotypes

et al. 2014

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Histochemical and biochemical muscle fibre properties are the factors that influence the quantitative and qualitative characteristics of pork meat. The aim of the study was to assess the influence of genetic effects of selected genetic markers MyoD genes and RYR1 on the achieved indicators of muscle fibres in the musculus longissimus lumborum et thoracis (MLLT). The study included a total number of 216 hybrid pigs with the mean slaughter weight of 123 kg. Gene polymorphism was determined by the PCR-RFLP method. The gene polymorphism was determined in the RYR1, MYOD1, MYOG, and MYF6 genes. Muscle fibre types from MLLT were identified. Concerning the RYR1 gene, the study found that homozygous-dominant animals reached a lower number of type I (8.35 vs. 10.52; P < 0.05) and a higher number of IIA (3.66 vs. 2.10; P < 0.05) and a higher number of IIB (76.61

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Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits

Cited by 36 publications

References 35 publications

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Association of <i>MyoD1</i> Gene Polymorphisms with Meat Quality Traits in Domestic Pigeons (<i>Columba livia</i>)

Histological characteristics of the musculus longissimus lumborum et thoracis muscle fibres in pigs in relation to selected RYR1, MYOG, MYOD1 and MYF6 genotypes

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