Effects of use of riboflavin and ultraviolet light for pathogen inactivation on quality of platelet concentrates

Stanojkovic, Zoran; Antić, Ana; Stojanović, Miodrag

doi:10.2298/vsp1106489s

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…Preclinical studies have revealed the effectiveness of reduction in infectivity of some viruses, including HIV-1, bovine viral diarrhea virus (BVDV), a model for HCV; single-stranded RNA virus), and pseudorabies virus, as well as bacteria in blood products [175–178]. …”

Section: Photodynamic Therapy As An Anti-infectivementioning

confidence: 99%

Light based anti-infectives: ultraviolet C irradiation, photodynamic therapy, blue light, and beyond

Yin

Dai

Avci

et al. 2013

Current Opinion in Pharmacology

238

172

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Owing to the worldwide increase in antibiotic resistance, researchers are investigating alternative anti-infective strategies to which it is supposed microorganisms will be unable to develop resistance. Prominent among these strategies, is a group of approaches which rely on light to deliver the killing blow. As is well known, ultraviolet light, particularly UVC (200–280nm), is germicidal, but it has not been much developed as an anti-infective approach until recently, when it was realized that the possible adverse effects to host tissue were relatively minor compared to its high activity in killing pathogens. Photodynamic therapy is the combination of non-toxic photosensitizing dyes with harmless visible light that together produce abundant destructive reactive oxygen species (ROS). Certain cationic dyes or photosensitizers have good specificity for binding to microbial cells while sparing host mammalian cells and can be used for treating many localized infections, both superficial and even deep-seated by using fiber optic delivered light. Many microbial cells are highly sensitive to killing by blue light (400–470 nm) due to accumulation of naturally occurring photosensitizers such as porphyrins and flavins. Near infrared light has also been shown to have antimicrobial effects against certain species. Clinical applications of these technologies include skin, dental, wound, stomach, nasal, toenail and other infections which are amenable to effective light delivery.

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Section: Photodynamic Therapy As An Anti-infectivementioning

confidence: 99%