Structural and functional changes in platelets during storage can lead to the loss of platelet reactivity and response. Our aim was to evaluate leukocyte-depleted platelet concentrates on storage days 0, 3 and 5, obtained by in-line filtration. In non-filtered platelet concentrates (NF-PC) group, 180 whole blood units were collected with quadruple blood bags and then compared to another group of 180 whole blood units (leukocyte-depleted platelet concentrates [LD-PC]), collected in Imuflex Whole Blood Filter Saving Platelets (WB-SP) bags with an integrated leukoreduction filter, with regard to the platelet quality and characteristics. The efficacy of the two techniques for platelet concentrate preparation was evaluated by white blood cell (WBC) and platelet count on day 0. The partial pressure of oxygen (pO2), pH, platelets positive for P-selectin (CD62P), CD63, cluster of differentiation 42b (CD42b), phosphatidylserine (PS), and mitochondrial membrane potential (MMP) were analyzed during the storage in both groups. A significantly lower WBC count and higher platelet count was observed in LD-PC compared to NF-PC group, indicating the overall efficacy of the first technique. During the 5-day storage, pH and pO2 decreased in both groups. In LD-PC group, higher pH, increased pO2 and decreased platelet surface expression of CD62P, CD63 and PS were observed compared to NF-PC group. In both groups, the percentage of CD42b positive platelets and MMP did not change significantly during the 5-day period. The assessment of different markers of platelet activation may be an effective tool in evaluating the quality of platelets during storage. A better understanding of platelet activation may provide new insights for developing a novel therapeutic approach in the manipulation of platelet aggregation.

Hepcidin may serve as a marker for better diagnosing and monitoring anemia and iron metabolism disorders in CKD.

No abstract

This article looks at the fields of psychoanalysis and psychiatry to read socialist Yugoslavia's complex international and political position. It argues that the history of postwar mental health professions in this country opens up a larger social and political story of liberalization and authoritarianism in socialist Eastern Europe. After 1948, the conflict with the Cominform, and split with the USSR, Yugoslavia went on to receive Western material help, as well as political support, and developed its own more liberal and internationally open brand of socialism, predicated on the ideas of workers' self-management and nonalignment. Yugoslav psychiatry and psychoanalysis became the most liberalized and Westernized professions in the region, but they also contributed to the operation of the violent "reeducation" program at Goli Otok, the most authoritarian and repressive political project in Yugoslav history aimed at "re-educating" pro-Stalinists in the Yugoslav Communist Party. In this article, those two sides of the Yugoslav psychiatric profession will be demonstrated through the prism of self-management. First, the article discusses the application of psychotherapeutic techniques and self-management in the violent context of re-education camps for political prisoners. A similar combination of psychoanalysis and principles of self-management in "civilian" and Westernized child psychiatry is analysed in the second part. The article shows how these very similar notions and ideological principles could be used within the same sociopolitical framework and by the same profession but for radically different purposes. In 1948, Yugoslavia, a newly socialist, revolutionary country, which had just emerged out of the most devastating conflict in its brief history, experienced yet

This article offers a transnational account of the historical origins and development of the concept of ‘global psyche’ and transcultural psychiatry. It argues that the concept of universal, global psyche emerged in the aftermath of the Second World War and during decolonization, when West European psychiatry strove to leave behind its colonial legacies and lay the foundation for a more inclusive conversation between Western and non-Western mental health communities. In the second half of the twentieth century, leading ‘psy’ professionals across the globe set about identifying and defining the universal psychological mechanisms supposedly shared among all cultures (and ‘civilizations’). The article explores this far-reaching psychiatric, social and cultural search for a new definition of ‘common humanity’, relating it to the social and political history of decolonization, and to the post-war reconstruction and search for stable peace. It provides a transnational account of a series of interlinked developments and trends around the world in order to arrive at a global history of the decolonization of mental health science.