Effects of Ultrasound on Osteotomy Healing in a Rabbit Fracture Model

Lai, Chien Hung; Chuang, Chiung Cheng; Li, Jimmy Kuan-Jung; Chen, Shih Ching; Chang, Walter

doi:10.1016/j.ultrasmedbio.2011.06.014

Cited by 15 publications

(9 citation statements)

References 59 publications

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“…25 Their results revealed that bone growth in the ultrasound-treated fibula at all frequencies was significantly greater than in the sham-treated group. 25 However, no difference was found in bone growth between the four different frequencies. This is in contrast to the results of the present study, and may be due to the small sample size in each group which could have affected the statistical significance.…”

Section: Discussionmentioning

confidence: 95%

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Bronoosh

Tanideh

Noorafshan

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 95%

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Bronoosh

Tanideh

Noorafshan

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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“…Rabbits are commonly used animals for the study of fracture repair. Beyond effects caused by pharmaceutical substances—especially growth factors— the studies examined are primarily concerned with mechanical influences like shock wave therapy, ultrasound, electromagnetic field, passive motion, or mechanical parameters as well as surgical techniques or materials . However, a standardized fracture model, which would be desirable at least for comparison of technical influences between different studies, does not exist.…”

Section: Animal Modelsmentioning

confidence: 99%

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

Reifenrath

Angrisani

Lalk

et al. 2013

J Biomedical Materials Res

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In the field of fracture healing it is essential to know the impacts of new materials. Fracture healing of long bones is studied in various animal models and extrapolated for use in humans, although there are differences between the micro- and macrostructure of human versus animal bone. Unfortunately, recommended standardized models for fracture repair studies do not exist. Many different study designs with various animal models are used. Concerning the general principles of replacement, refinement and reduction in animal experiments (three "Rs"), a standardization would be desirable to facilitate better comparisons between different studies. In addition, standardized methods allow better prediction of bone healing properties and implant requirements with computational models. In this review, the principles of bone fracture healing and differences between osteotomy and artificial fracture models as well as influences of fixation devices are summarized. Fundamental considerations regarding animal model choice are discussed, as it is very important to know the limitations of the chosen model. In addition, a compendium of common animal models is assembled with special focus on rats, rabbits, and sheep as most common fracture models. Fracture healing simulation is a basic tool in reducing the number of experimental animals, so its progress is also presented here. In particular, simulation of different animal models is presented. In conclusion, a standardized fracture model is of utmost importance for the best adaption of simulation to experimental setups and comparison between different studies. One of the basic goals should be to reach a consensus for standardized fracture models.

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“…Growth factors such as bone morphogenetic proteins (BMPs) and transforming growth factor (TGF)-β can regulate and stimulate bone formation. To investigate this hypothesis, further studies and measuring the BMP and TGF plasma level are required after treatment with ultrasound (31).…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, Tsai et al studied osteotomy operation on fibular bone in rabbits and showed ultrasound therapy improves bone growth on the opposite side of the treated fracture. Chung et al reported new bone formation on contralateral side (sham group) by using ultrasound therapy in osteotomy(30)(31)(32). On the other hand, many researchers have tried to consider the systemic effect of ultrasound on osteoporosis disease, yet their efforts have not been successful.…”

mentioning

confidence: 99%

Evaluation of Low Intensity Pulsed Ultrasound Effects on the Osteogenesis Potential of Demineralized Bone Matrix in Experimental Tibial Defect in Rabbits

Givi

Baniadam

Esmaeilzadeh

et al. 2016

Jentashapir J Health Res

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Background: Many studies have assessed the effects of either low intensity pulsed ultrasound (LIPUS) or demineralized bone matrix (DBM) on bone repair; however, an evaluation of the combination of these modalities (LIPUS + DBM) has not yet been considered.Objectives: This study aimed to investigate combined effects of DBM and LIPUS on fracture healing. Methods: Bilateral 5-mm tibial defects were created in male Dutch rabbits (n = 30). Animals were divided to two groups of empty defect (A) and DBM group (B), in which commercial DBM putty was used in defects. In each animal left tibia was treated with LIPUS (intensity = 30 mW/cm 2 , I SATA, 1 MHz, 20 min/day, pulsed duty 1:4) and the contralateral limb was used as the control. Animals, after 14, 28 and 60 days, were submitted to radiographic or computerized tomography (CT) scanning analysis.Results: At two weeks, LIPUS had no substantial effect on bone formation. Slight increase of average rates in LIPUS group (A2) were seen compared to the empty defect group (A1) at day 21 and 28. In the DBM-treated group compared with the sham LIPUS, bone-healing rate was reduced at the end of the period (60 days) after surgery. The average healing rate in group B at the end of the 60-day period was less than group A after 21 days. Conclusions:The present study discusses systemic effect of LIPUS because of non-significant results between treated group and control group and is the first to demonstrate that LIPUS decreases bone formation induced by DBM.

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Effects of Ultrasound on Osteotomy Healing in a Rabbit Fracture Model

Cited by 15 publications

References 59 publications

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Effects of low-intensity pulsed ultrasound on healing of mandibular bone defects: an experimental study in rabbits

Replacement, refinement, and reduction: Necessity of standardization and computational models for long bone fracture repair in animals

Evaluation of Low Intensity Pulsed Ultrasound Effects on the Osteogenesis Potential of Demineralized Bone Matrix in Experimental Tibial Defect in Rabbits

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