Effects of UCMS-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater

Zhang, Mingjie; Dai, Wei; Liang, Jingyao; Chen, Xiaoyan; Hu, Yueqing; Chu, Bingqian; Pan, Meiyan; Dong, Zhao; Yu, Shengyuan

doi:10.1016/j.neulet.2013.04.038

Cited by 14 publications

(15 citation statements)

References 29 publications

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“…In the acetone test, there was a positive correlation between the pain-like responses and the level of IL-1β and IL-10 gene expression in amygdala of the brain [69]. Besides the commonly used animal models of sensory pain, one study reported that CUMS-induced depression exacerbated trigeminovascular nociception, a rodent model of migraine [70]. …”

Section: Animal Studies Of the Pain-depression Relationshipmentioning

confidence: 99%

Pain and depression comorbidity: A preclinical perspective

2015

Behavioural Brain Research

134

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Pain and depression are two highly prevalent and deleterious disorders with significant socioeconomic impact to society. Clinical observations have long recognized the co-existence and interactions of pain and depression. However, the underlying mechanisms of pain-depression comorbidity and their dynamic interactions remain largely unknown. Preclinical animal studies may provide critical information for the understanding of this important comorbidity. This review analyzed the current preclinical evidence of interactions between pain and depression, which generally supports the causative relationship of the two conditions. In addition, the analysis proposed to apply domain interplay concept in future model development of pain-depression comorbidity and mechanism studies. The application of spectrum-centered animal models will better the understanding of pain-depression dyad and foster the development of more effective therapeutic strategies.

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Section: Animal Studies Of the Pain-depression Relationshipmentioning

confidence: 99%

Pain and depression comorbidity: A preclinical perspective

2015

Behavioural Brain Research

134

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“…Then the obturator cap was removed from the electrode fixtures, and an internal delivery electrode tip was inserted, which was connected to the current external output port of an electrical stimulator (YC-2 stimulator, Chengdu Instrument, Co.). On the basis of previous studies [19, 20, 26] and our own optimization of stimulation, effective dural stimuli consisted of monophasic square-wave pulses with a pulse duration of 0.5 ms at an intensity of 1.8–2.0 mA and frequency of 20 Hz, and stimulation was administered to rats in the EA, SA, and Model groups for 15-minute every other day for 3 sessions. The rats in the Control group were also connected to the stimulator, but they received no electrical stimulation.…”

Section: Methodsmentioning

confidence: 99%

“…To test this hypothesis, we chose a rat model of recurrent migraine induced by repeated electrical stimulation of the dura surrounding the superior sagittal sinus (SSS), which is an established paradigm of migraine-associated pain [19, 20]. We evaluated the antinociceptive effect of EA on the migraine-like behaviors, such as change in rest, freezing, grooming, and exploration behaviors.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats

Liu

Pei

Zhao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Background. While electroacupuncture (EA) pretreatment in migraine has been found to attenuate pain and frequencies of attacks, the underlying mechanism of its antinociceptive effect remains poorly understood. Emerging evidence suggests that the serotonin system may be involved in migraine pathophysiology. Method. Forty male Sprague-Dawley rats were randomly assigned to Control, Model, EA, and sham acupuncture (SA) groups. HomeCageScan was used to measure the effects on spontaneous nociceptive behaviors. Radioimmunoassay and high-performance liquid chromatography were used to evaluate the expression of 5-hydroxytryptamine (HT) in the plasma and three-key structure of the descending pain modulatory system. Results. Our study showed that EA pretreatment could produce a significant reduction in resting, freezing, and grooming behavior and a significant increase in exploration behavior. Furthermore, we found that the level of 5-HT in plasma was significantly increased, and it was significantly decreased in the descending pain modulatory system in Model group. The aforementioned results were significantly reversed in EA group; that is, the level of 5-HT was increased in the rostroventromedial medulla (RVM) and trigeminal nucleus caudalis (TNC) region and decreased in the plasma. Conclusion. EA pretreatment exerts antinociceptive effects in a rat model of recurrent migraine, possibly via modulation of the serotonin system.

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“…In a mouse model of trigeminal pain, masseter muscle was unilaterally injected with Freund's adjuvant and facial grooming patterns such as forepaw rubbing and hind paw scratching directed to the injection area were analysed (Romero-Reyes et al, 2013a). Pain-related behaviours can also be elicited in rats with superior sagital sinus stimulation (Zhang et al, 2013a). With some modifications of the technique for use in conscious animals, the researchers detected a stimulation frequency-dependent alteration of grooming and head-flick activities, which were reversed by morphine and rizatriptan (Dong et al, 2011).…”

Section: Pain-related Behaviourmentioning

confidence: 99%

Modelling headache and migraine and its pharmacological manipulation

Erdener

Dalkara

2014

British J Pharmacology

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Similarities between laboratory animals and humans in anatomy and physiology of the cephalic nociceptive pathways have allowed scientists to create successful models that have significantly contributed to our understanding of headache. They have also been instrumental in the development of novel anti-migraine drugs different from classical pain killers. Nevertheless, modelling the mechanisms underlying primary headache disorders like migraine has been challenging due to limitations in testing the postulated hypotheses in humans. Recent developments in imaging techniques have begun to fill this translational gap. The unambiguous demonstration of cortical spreading depolarization (CSD) during migraine aura in patients has reawakened interest in studying CSD in animals as a noxious brain event that can activate the trigeminovascular system. CSD-based models, including transgenics and optogenetics, may more realistically simulate pain generation in migraine, which is thought to originate within the brain. The realization that behavioural correlates of headache and migrainous symptoms like photophobia can be assessed quantitatively in laboratory animals, has created an opportunity to directly study the headache in intact animals without the confounding effects of anaesthetics. Headache and migraine-like episodes induced by administration of glyceryltrinitrate and CGRP to humans and parallel behavioural and biological changes observed in rodents create interesting possibilities for translational research. Not unexpectedly, species differences and model-specific observations have also led to controversies as well as disappointments in clinical trials, which, in return, has helped us improve the models and advance our understanding of headache. Here, we review commonly used headache and migraine models with an emphasis on recent developments.

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Effects of UCMS-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater

Cited by 14 publications

References 29 publications

Pain and depression comorbidity: A preclinical perspective

Pain and depression comorbidity: A preclinical perspective

Electroacupuncture Pretreatment at GB20 Exerts Antinociceptive Effects via Peripheral and Central Serotonin Mechanism in Conscious Migraine Rats

Modelling headache and migraine and its pharmacological manipulation

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