Effects of Turkish pollen and propolis extracts on respiratory burst for K-562 cell lines

Aliyazıcıoğlu, Yüksel; Ovalı, Ercüment; Barlak, Yaşam; Hosver, Ilgin; Tekelioğlu, Yavuz; Karahan, Süleyman Caner

doi:10.1016/j.intimp.2005.04.005

Cited by 28 publications

(26 citation statements)

References 17 publications

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“…27 Compared to Brazilian propolis, which contains 2% to 4% flavonoids, European propolis contains an average of 20% to 25% of this substance. 28 Kumazawa et al 23 investigated the in vitro antioxidant activity of various propolis samples from various geographic origins and concluded that it was difficult to evaluate the quality of propolis without the knowledge of the constituents and quantitative values in propolis.…”

Section: Discussionmentioning

confidence: 99%

Systemic propolis stimulates new bone formation at the expanded suture

Altan

Kara

Nalçacı

et al. 2012

The Angle Orthodontist

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Objective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups-only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation. Results: Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries. Conclusion: Systemic use of propolis may hasten new bone formation at the expanded suture in rats. (Angle Orthod. 2013;83:286-291.)

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Section: Discussionmentioning

confidence: 99%

Systemic propolis stimulates new bone formation at the expanded suture

Altan

Kara

Nalçacı

et al. 2012

The Angle Orthodontist

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“…The effect of propolis on inhibition of different cell lines were reported for different cell lines such as K-562 (Aliyazicioglu et al 2005) HL-60 cells (Akao et al 2003;Mishima et al 2005), MCF-7 human breast cancer cells (Luo et al 2001) or some other leukemia cells (Hamblin 2006). There are number of reports indicating that some specific chemicals present in propolis such as caffeic acid phenethyl ester (CAPE) can inhibit growth of mutated cells without harming normal cells (Guarini et al 1992;Rao et al 1993).…”

Section: Discussionmentioning

confidence: 99%

Effect of the water extracts of propolis on stimulation and inhibition of different cells

et al. 2007

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The water extracts of propolis (WEP) could inhibit growth of different cell lines namely McCoy, HeLa, SP2/0, HEp-2, and BHK21 and stimulate growth of normal cell named human lymphocyte, rat kidney, rat liver, and rat spleen. In these experiments 1 and 2 mg of WEP were added to 1 ml RPMI media with 5% FCS. Cell counts and cell viability of propolis-treated and propolis-free cells were assessed by Trypan blue dye exclusion test and MTT assay. The results showed that in case of McCoy, HeLa, SP20, HEp-2, and BHK21 cell lines, the water extracts of propolis could inhibit cell growth as well as reduction on size of the cells. In contrast the same amount of WEP could stimulate growth of normal cells up to 60% with the same concentration used for cell lines. Thus our study indicates that although WEP consists only of the soluble part of propolis, it enables to inhibit different cell lines and increase growth of normal cells. This indicates also that WEP contains the specific compounds with bioactivity against cell lines. Although propolis contain different number of compounds it is clear that WEP has enough biological compounds useful for the treatment of some diseases, medical and related applications.

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“…1,5 Valuable information have been revealed about antioxidant, antibacterial, antiviral, antiinflammatory, anticancer, antimutagenic, radioprotective, and other beneficial biological effects and chemical structure of propolis. 6,7,8,9,10 In recent years, propolis has become quite popular in pharmaceutical, cosmetic, and food industries because of above-mentioned properties that it possesses. 6,11 Flavonoids are natural polyphenolic compounds that can be found in fruits, vegetables, and beverages, such as tea, wine, and fruit juice.…”

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confidence: 99%

“…13,14 Recent studies have showed that flavonoids protect DNA and other components of the cell from oxidative damage. 10,15,16 Free radicals are defined as atoms or groups of atoms that includes an unpaired electrons. Reactive oxygen species (ROS) are described as chemically reactive molecules that include one or more oxygen atoms, which contain free radicals and non-radical reactive compounds that can oxide biological molecules.…”

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confidence: 99%

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Mısır¹,

Aliyazıcıoğlu²,

Demir³

et al. 2018

IJPER

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Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H 2 DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.

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Effects of Turkish pollen and propolis extracts on respiratory burst for K-562 cell lines

Cited by 28 publications

References 17 publications

Systemic propolis stimulates new bone formation at the expanded suture

Systemic propolis stimulates new bone formation at the expanded suture

Effect of the water extracts of propolis on stimulation and inhibition of different cells

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

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