Effects of Tumor Growth on Serum Glycoprotein Concentrations in the Rat2

Weimer, Henry E.; Quinn, Frances A.; Redlich-Moshin, Jean; Nishihara, Hisako

doi:10.1093/jnci/19.3.409

Cited by 27 publications

(7 citation statements)

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“…The tumor-bearing animals in some cases showed the appearance of new serum proteins [1,3]. The results of this paper indicate that in hamsters bearing tumors, serum globulin changes occur.…”

Section: Discussionmentioning

confidence: 60%

“…In previous reports of serum changes in tumor-bearing rats [1][2][3], the a-globulins most often showed significant changes. The tumor-bearing animals in some cases showed the appearance of new serum proteins [1,3].…”

Section: Discussionmentioning

confidence: 99%

“…A number of independent observations [1][2][3][4] have indicated that in tumor bearing rats changes occur in the x-globulins of serum. These changes have been reported in rats harboring either chemically-induced primary tumors or transplantable tumors.…”

Section: Introductionmentioning

confidence: 99%

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Serum Globulin Changes in Tumor-Bearing Hamsters

Jw²,

et al. 1973

Oncology

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Serum Globulin Changes in Tumor-Bearing Hamsters

Jw²,

et al. 1973

Oncology

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“…The Walker 256 carcinoma was chosen for this work as it could be made to grow subcutaneously as a discrete, encapsulated tumour and under these conditions did not metastasise to the liver. This tumour is also known to produce changes in the serum al-globulin level similar to those found in human cancer (Darcy, 1957;Weimer, Quinn, Redlich-Moshin and Nishihara, 1957). A preliminary account of our work has been published previously (Burston et al, 1963;Burston, Apsey, Tombs and Maclagan, 1963).…”

supporting

confidence: 53%

Further Observations on the Effects of Tumours on the Perchloric Acid Soluble Proteins of the Rat

Burston¹,

Apsey²,

Maclagan³

1965

Br J Cancer

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“…of plasma or serum glycoproteins that accompanies malignant disease in the human (1-5) and in the laboratory animal bearing a transplantable tumor (6-10). Available evidence would suggest that the observed elevation occurs largely, if not exclusively, in the seromucoid fraction of the plasma proteins (8,9). This fraction, which is not precipitable by boiling a t slightly acid pH, is defined as a group of protein-carbohydrate complexes occurring in plasma that are soluble in 0.6 M prchloric acid but insoluble in 1 1ll phosphotungstic acid (11).…”

mentioning

confidence: 99%

The Effect of Oxyphenbutazone (Tandearil) on the Level of the Seromucoid Fraction of Rats Bearing Walker 256 Carcinoma

Macbeth¹,

Martín²

1966

Can. J. Biochem.

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The effect of oxyphenbuhzorne (Tandearil) on the seromucoid proteila and seromucoid-bound carbohydrates of Walker 256 carci~lon~a bearing rats has beer1 investigated. InitiaHy, treatment is associated with increased tumor growth and slappression of the anticipated glycoprotein response in the serum. After the eighth day, tumor growth ceases in treated animals and the serum glycoproteins manifest progressive elevations which are, however, less than those observed in untreated tumor-bearing controls. The survival time of treated animals exceeded that of untreated tramor-bearing animals, and treated animals were free of gross malignant disease a t the time of death.Studies from anany laboratories have amply confirmed the elevation. of plasma or serum glycoproteins that accompanies malignant disease in the human (1-5) and in the laboratory animal bearing a transplantable tumor (6-10). Available evidence would suggest that the observed elevation occurs largely, if not exclusively, in the seromucoid fraction of the plasma proteins (8,9). This fraction, which is not precipitable by boiling a t slightly acid pH, is defined as a group of protein-carbohydrate complexes occurring in plasma that are soluble in 0.6 M prchloric acid but insoluble in 1 1ll phosphotungstic acid (11).Recent investigations have focused on a search for the source of the elevated plasma glycoproteins observed in malignant disease and a wide variety of acute and chronic inflammatory states. I t appears clear that in the normal anirnlal the protein binding of carbohydrates and synthesis of glycoproteins occur in the

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Effects of Tumor Growth on Serum Glycoprotein Concentrations in the Rat2

Cited by 27 publications

References 0 publications

Serum Globulin Changes in Tumor-Bearing Hamsters

Serum Globulin Changes in Tumor-Bearing Hamsters

Further Observations on the Effects of Tumours on the Perchloric Acid Soluble Proteins of the Rat

The Effect of Oxyphenbutazone (Tandearil) on the Level of the Seromucoid Fraction of Rats Bearing Walker 256 Carcinoma

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