Effects of Triterpenoid From Schisandra chinensis on Oxidative Stress in Alcohol-Induced Liver Injury in Rats

Abstract

Alcohol-induced oxidative stress plays a crucial role in the pathological development of alcoholic liver disease. The aim of this study was to investigate the effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. We found that the administration of triterpenoid attenuated alcohol-induced oxidative stress in multiple organs including liver. Moreover, the impaired liver function and histological changes resulted from alcohol consumption was improved by triterpenoid treatment. Finally, we found that pretreatment with triterpenoid from Schisandra chinensis to alcohol-fed rats increased the expression level of haem oxygenase-1 (HO-1) while inhibited the induction of cytochrome P-450 2E1 (CYP2E1) in liver microsomes. Further assays revealed that the microsomal activity of HO-1 was accordingly induced whereas CYP2E1 was suppressed in rats received triterpenoid intervention. Our findings suggest that triterpenoid from Schisandra chinensis may protect against alcohol-induced liver injury through ameliorating oxidative stress in rats.

Effects of Huang Qi Decoction on Endothelial Dysfunction Induced by Homocysteine

“…Liuwei Di Huang, a traditional Chinese herbal formula containing Rehmannia , is demonstrated to suppress chronic inflammation and oxidative stress in obese rats [ 8 ]. Triterpenoid or 5-hydroxymethylfurfural from Schisandra is reported to have favorable antioxidant effects on alcoholic liver oxidative injury [ 9 , 10 ]. A report demonstrates that Gua Lou Guizhi decoction exerts neuroprotective effect by enhancing endogenous antioxidant enzymatic activities [ 11 ].…”

Soyasaponin bb protects rat hepatocytes from alcohol-induced oxidative stress by inducing heme oxygenase-1

“…[15] The optical density ratio of the protein product to β-actin was obtained and expressed as percentage or ratio of the control value in the figures.…”

“…[1112] Research showed that the induction of cytochrome P450-2E1 (CYP2E1) was the material cause for the generation of ROS and oxidative stress. [131415] The generated ROS could initiate lipid peroxidation, which directly damaged intracellular membranes and plasma. The production of reactive aldehydes negatively influences liver or other vital organs with profibrotic properties and potent proinflammatory.…”

Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries

“…Besides, 5‐hydroxymethyl‐2‐furfural (5‐HMF) in Schisandra chinensis was reported to dose‐dependently protect the mouse liver with potent antioxidant activities (Li et al., ). Furthermore, alleviating oxidative stress and inflammatory response was observed in vivo , when the rodents were fed with triterpene compounds of Schisandra chinensis , total flavones of loquat flower ( Eriobotrya japonica ), and platycodin D of Platycodon grandiflorum (Li et al., , ; Wu et al., ).…”