Effects of Treatment with L-thyroxin on Glucose Regulation in Patients with Subclinical Hypothyroidism

Bilic-Komarica, Edina; Bećiragić, Amela; Junuzović, Dželaludin

doi:10.5455/medarh.2012.66.364-368

Cited by 19 publications

(11 citation statements)

References 16 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…al (1996) (11), found that the diastolic dysfunction is present in both sub-clinical and over hypothyroidism while pericardial effusion is seen only in overt hypothyroidism and mean serum cholesterol is significantly raised in oth sub-clinical and overt hypothyroidism with respect to control group. Simmilar results presented by B&H authors (12, 13). …”

Section: Discussionmentioning

confidence: 84%

Assessment of Left Ventricular Diastolic Dysfunction in Sub-clinical Hypothyroidism

Meena

Meena²,

Nawal³

et al. 2012

Acta Inform Med

View full text Add to dashboard Cite

Background:Adverse cardiovascular effect of hypothyroidism has been identified in many studies. Early identification of patients with sub-clinical hypothyroidism may lead to early treatment and thereby favourable effect on cardiovascular morbidity and mortality.Objectives:To find out the association of sub clinical hypothyroidism and left ventricular dysfunction and also to find out relationship between systolic and diastolic dysfunction in these patients.Material and Methods:A total 30 cases of sub clinical hypothyroidism along with 15 age sex matched healthy control subjects were included in study. Serum TSH, T4, T3 hormone level was measured and those who were found to have sub-clinical hypothyroidism underwent for 2DEcho.Results:Significant reduction in peak early filling velocity (PE) (p<0.001) and early filling time velocity integral (Ei) (p<0.001). Ratio of early and late peak velocities (PE/PA) (p<0.001), ratio of time velocity integral of early and atrial filling (Ei/Ai) (p<0.001) and ratio of the early peak to average velocity (PE/M) (p<0.001) were also reduced. Mean EF was 54.9± 5.55 as compared to 55.7 ± 3.46 of control subjects with a T.value of 0.48 ,however there was significant diastolic dysfunction in case of hypothyroid patients (mean Ei/Ai = 1.35 ± 0.53) as compared to control group subjects (mean Ei/AI = 2.11 ± 0.26) with a T value of 5.22.Conclusion:Sub-clinical hypothyroidism showed significant diastolic dysfunction in the absence of significant impairment of systolic function.

show abstract

Section: Discussionmentioning

confidence: 84%

Assessment of Left Ventricular Diastolic Dysfunction in Sub-clinical Hypothyroidism

Meena

Meena²,

Nawal³

et al. 2012

Acta Inform Med

View full text Add to dashboard Cite

show abstract

“…They found a positive correlation between HbA1c and TSH and positive correlation between HbA1c and insulin. Thus they concluded that normalised TSH levels will result in decreased levels of fasting insulin, FBS, PPBS and HbA1c Edina Bilic-Komarica et al (3) conducted a study to understand the effects of treatment of L-thyroxine on glucose regulation in patients with subclinical hypothyroidism. The study group consisted of 100 patients, out of which 38 patients were diabetic.…”

Section: Discussionmentioning

confidence: 99%

A Study on Correlation Between Hba1c Levels With TSH Levels in Patients With Hypothyroidism and Type 2 Diabetes Mellitus

Kandasamy¹,

Thilakavathi²,

Vallathol³

et al. 2016

jemds

View full text Add to dashboard Cite

BACKGROUNDDiabetes and hypothyroidism are two common metabolic disorders that are interrelated. The hallmarks of hypothyroidism are decreased absorption of glucose from the intestinal tract along with increased accumulation of glucose in the periphery with decreased glucose production from the liver and decreased use of glucose. For those who have subclinical or overt hypothyroidism, insulin resistance causes glucose stimulated increase in insulin secretion. Moreover, those with subclinical hypothyroidism have an independent risk for insulin resistance, especially in the muscle and adipose tissue. Hence, there is a definite link between hyperinsulinaemia, resistance to insulin and subclinical hypothyroidism.

show abstract

“…On the contrary, other authors have showed a significant worsening of glucose levels at the followup supporting the role of subclinical hypothyroidism in glucose regulation. 23 In conclusion, in CHD patients with subclinical hypothyroidism, most of whom had a thyroidstimulating hormone concentration between 5 and 10 mIU/L, no changes were seen in serum thyroxine, glucose, cholesterol, or C-reactive protein concentrations before and after the follow-up regardless of whether they were or not under thyroid hormone replacement therapy. Although our small sample size, non-randomised design, can limit the result of our study we must consider a proper follow-up, especially in CHD patients with thyroid-stimulating hormone concentration above 10 mIU/L, with heart failure, 24 or at an increased risk for cardiovascular events.…”

Section: Type Of Congenital Malformations Patientsmentioning

confidence: 74%

Follow-up of congenital heart disease patients with subclinical hypothyroidism

Martínez‐Quintana

Rodríguez‐González

2014

Cardiol Young

View full text Add to dashboard Cite

show abstract

Effects of Treatment with L-thyroxin on Glucose Regulation in Patients with Subclinical Hypothyroidism

Cited by 19 publications

References 16 publications

Assessment of Left Ventricular Diastolic Dysfunction in Sub-clinical Hypothyroidism

Assessment of Left Ventricular Diastolic Dysfunction in Sub-clinical Hypothyroidism

A Study on Correlation Between Hba1c Levels With TSH Levels in Patients With Hypothyroidism and Type 2 Diabetes Mellitus

Follow-up of congenital heart disease patients with subclinical hypothyroidism

Contact Info

Product

Resources

About