A Study on Correlation Between Hba1c Levels With TSH Levels in Patients With Hypothyroidism and Type 2 Diabetes Mellitus

Abstract

BACKGROUNDDiabetes and hypothyroidism are two common metabolic disorders that are interrelated. The hallmarks of hypothyroidism are decreased absorption of glucose from the intestinal tract along with increased accumulation of glucose in the periphery with decreased glucose production from the liver and decreased use of glucose. For those who have subclinical or overt hypothyroidism, insulin resistance causes glucose stimulated increase in insulin secretion. Moreover, those with subclinical hypothyroidism have an independent risk for insulin resistance, especially in the muscle and adipose tissue. Hence, there is a definite link between hyperinsulinaemia, resistance to insulin and subclinical hypothyroidism.

Serum retinol binding protein-4 and the risk of hypothyroidism in Egyptian diabetic patients with cardiovascular manifestations

“…In terms of diabetes indicators, our findings demonstrated a highly statistically significant difference in FBG between the patient groups and the control group (P<0.001). Furthermore, HbA1c levels changed slightly across patient groups (P<0.001), while Insulin and HOMA-IR values differ considerably from the control group (P<0.001) which is supported by previous studies on T2DM patients [33,34] Regarding the lipid profile, our study revealed that the mean concentration of TC in (T2DM+Hyp+CVD) group was significantly higher than its concentration in other groups (312±53.8). There were statistically differences in all groups regarding TG concentration.…”