Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas

Chiyaka, Christinah; Garira, Winston; Dube, Simiso

doi:10.1016/j.tpb.2008.10.002

Cited by 52 publications

(43 citation statements)

References 43 publications

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“…Information on the epidemiology of resistance can be applied to the monitoring and control of the appearance and propagation of chemoresistance in populations of natural parasites. This monitoring can be performed with drugs in use in a particular location or with new drug alternatives, especially when the parasite exhibits cross-resistance to drugs (Ferreira et al 2007, Chiyaka et al 2009). The stabilised field isolates developed and examined in the present study exhibited similar sensitivity profiles to chloroquine, quinine and artemisinin.…”

Section: Discussionmentioning

confidence: 99%

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

Silva

Magalhães

Costa

et al. 2012

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

Silva

Magalhães

Costa

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…For our model, we augment the basic SIR model to include preventative measures as seen previously by other researchers [3,4,5]. We include the effects of ITNs and IRS preventative measures based on the fact that both methods are recommended for the prevention of malaria by the WHO.…”

Section: Model Formationmentioning

confidence: 99%

“…The SIR model is a simple model useful for modeling diseases such as chicken pox and influenza [15]. Modern epidemiology ODE models are based on these same SIR concepts of populations flowing between states [1,3,5,11,13]. For our model, we will apply the basic concepts of the SIR model to the vector-borne disease malaria.…”

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confidence: 99%

Modeling the Effects of Malaria Preventative Measures

Griffin

2013

SIURO

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Malaria is a serious and sometimes fatal epidemic affecting nearly half of the world's population and is the 5th leading cause of death by infectious disease world-wide. There are currently two recommended methods for prevention and eradication of the disease: insecticide-treated mosquito nets (ITNs) and indoor residual spraying (IRS), but efficacies and compliance vary from region to region. In this project, we look at the effects of ITNs and IRS as methods for eradication of malaria. To compare these methods, we develop a differential equation model and apply the next generation matrix method to determine the basic reproductive number. The differential equation model builds on classical SIR epidemiological models, with added constraints for the two preventative measures. Analysis shows that the effects of ITNs and IRS can help eradicate the disease. We find that the effect of ITNs is significantly greater than the effect of IRS. We conclude that the combination of compliance and efficacy for ITNs needs to be at least 61% and that there is no such percentage for IRS alone that will eradicate the disease. At a minimum, in combination, compliance and efficacy for ITNs needs to be at least 60% and compliance and efficacy for IRS needs to be at least 60%.

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“…Mathematical models of pathogen population dynamics, by virtue of their ability to provide a quantitative means for integrating and simulating the impacts of multi-factorial and multi-scale disease transmission processes, may offer us a particularly pertinent methodological tool for developing such holistic predictive and investigative frameworks [7][8][9][10][11][12][13]19,25,27,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Recent advances in incorporating the effects of climate, as well as anthropogenic alterations of ecosystems (e.g.…”

Section: Introductionmentioning

confidence: 99%

Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission

Parham

Waldock

Christophides

et al. 2015

Phil. Trans. R. Soc. B

230

224

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Arguably one of the most important effects of climate change is the potential impact on human health. While this is likely to take many forms, the implications for future transmission of vector-borne diseases (VBDs), given their ongoing contribution to global disease burden, are both extremely important and highly uncertain. In part, this is owing not only to data limitations and methodological challenges when integrating climate-driven VBD models and climate change projections, but also, perhaps most crucially, to the multitude of epidemiological, ecological and socio-economic factors that drive VBD transmission, and this complexity has generated considerable debate over the past 10–15 years. In this review, we seek to elucidate current knowledge around this topic, identify key themes and uncertainties, evaluate ongoing challenges and open research questions and, crucially, offer some solutions for the field. Although many of these challenges are ubiquitous across multiple VBDs, more specific issues also arise in different vector–pathogen systems.

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Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas

Cited by 52 publications

References 43 publications

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

Modeling the Effects of Malaria Preventative Measures

Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission

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