Effects of Traumeel (Tr14) on Exercise-Induced Muscle Damage Response in Healthy Subjects: A Double-Blind RCT

Abstract

The present double-blind, randomized, placebo-controlled clinical trial intended to test whether ingestion of a natural combination medicine (Tr14 tablets) affects serum muscle damage and inflammatory immune response after downhill running. 96 male subjects received Tr14 tablets, which consist of 14 diluted biological and mineral components, or a placebo for 72 h after the exercise test, respectively. Changes in postexercise levels of various serum muscle damage and immunological markers were investigated. The area under the curve with respect to the increase (AUCi) of perceived pain score and creatine kinase (CK) were defined as primary outcome measures. While for CK the p value of the difference between the two groups is borderline, the pain score and muscle strength were not statistically significant. However, a trend towards lower levels of muscle damage (CK, p = 0.05; LDH, p = 0.06) in the Tr14 group was shown. Less pronounced lymphopenia (p = 0.02), a trend towards a lower expression of CD69 count (p = 0.07), and antigen-stimulated ICAM-1 (p = 0.01) were found in the verum group. The Tr14 group showed a tendentially lower increase of neutrophils (p = 0.10), BDNF (p = 0.03), stem cell factor (p = 0.09), and GM-CSF (p = 0.09) to higher levels. The results of the current study indicate that Tr14 seems to limit exercise-induced muscle damage most likely via attenuation of both innate and adaptive immune responses. This study was registered with ClinicalTrials.gov (NCT01912469).

Calf Blood Compound (CFC) and Homeopathic Drug Induce Differentiation of Primary Human Skeletal Muscle Cells

“…On the other hand, Homeopathic Drug was reported to have bioregulatory effects in the treatment of acute musculoskeletal injuries [27,28]. Schneider [29] described the evidence of Homeopathic Drug's action on the inflammatory process, and of its efficacy and tolerability in randomized trials.…”

Deep Sequencing Transcriptome Analysis of Murine Wound Healing: Effects of a Multicomponent, Multitarget Natural Product Therapy-Tr14

“…The exact mechanisms of action are not known, but a number of studies suggest anti-inflammatory (Porozov et al, 2004 ; Birnesser and Stolt, 2007 ) and antioxidative properties (Baldwin and Bell, 2007 ; Zilinskas et al, 2011 ). Tr14 has shown effects on cellular and cytokine levels in randomized, double-blind controlled trials (RCTs) of exercise-induced muscle trauma (Pilat et al, 2015 ; Muders et al, 2016 , 2017 ), and demonstrated pain relief in acute ankle sprains (Gonzalez de Vega et al, 2013 ), with substantial evidence indicating a beneficial role in inflammation and wound repair (Wolfarth et al, 2013 ).…”

Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo

“…The more common treatment regimen described a few years later with the application of CFC and Tr14 in combination on day zero, two, and four after injury was described to result in a faster return-to-practice and return-to-play [19]. Tr14 was also demonstrated to have bio-regulatory effects in the treatment of musculoskeletal injuries in exercise induced inflammation [29][30][31][32], and comparable effectiveness to NSAIDs for the reduction in symptoms of inflammation [29].…”

“…These mechanisms could explain the protective properties of CFC injection therapy as observed clinically and in our animal studies following muscle tears. The ability of Tr14 to reduce inflammation [29][30][31][32] could be the potentiating effect that accelerates regeneration in the group administered the combined CFC and Tr14 therapy.…”