Effects of traditional medical herbs “minor bupleurum decoction” on the non-specific immune responses of white shrimp ( Litopenaeus vannamei )

Wu, Yu‐Sheng; Lee, Meng–Chou; Huang, Chen‐Fen; Kung, Tzu-Chi; Huang, Chih‐Yang; Nan, Fan-Hua

doi:10.1016/j.fsi.2017.03.018

Cited by 41 publications

(15 citation statements)

References 40 publications

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“…When invertebrates are infected by pathogens, oxygen is released to enhance their resistance. An important indicator of crustacean cellular defense is the production of ROS, which is essential for normal cell function (e.g., redox signaling and anti-microbial responses); however, excessive ROS can induce oxidative damage, organ dysfunction, as well as DNA, protein, enzyme, and cell membrane destruction (Halliwell, 2006 ; Qin et al, 2016 ; Wu et al, 2017 ). SOD can convert harmful

into hydrogen peroxide and then degrade the hydrogen peroxide product through GSH-Px to protect cells from oxidative damage (Holmblad and Söderhäll, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Melatonin Promotes Cheliped Regeneration, Digestive Enzyme Function, and Immunity Following Autotomy in the Chinese Mitten Crab, Eriocheir sinensis

Zhang

Yang

et al. 2018

Front. Physiol.

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In the pond culture of juvenile Eriocheir sinensis, a high limb-impairment rate seriously affects the culture success. Therefore, it is particularly important to artificially promote limb regeneration. This study evaluated the effects of melatonin on cheliped regeneration, digestive ability, and immunity, as well as its relationship with the eyestalk. It was found that the injection of melatonin significantly increased the limb regeneration rate compared with the saline group (P < 0.05). The qRT-PCR results of growth-related genes showed that the level of EcR-mRNA (ecdysteroid receptor) and Chi-mRNA (chitinase) expression was significantly increased following the melatonin injection, while the expression of MIH-mRNA (molt-inhibiting hormone) was significantly decreased (P < 0.05). Melatonin significantly increased lipase activity (P < 0.05). We observed that the survival rates of limb-impaired and unilateral eyestalk-ablated crabs were substantially improved following melatonin treatment, whereas the survival of the unilateral eyestalk-ablated crabs was significantly decreased compared with the control group (P < 0.05). Furthermore, the results of serum immune and antioxidant capacity revealed that melatonin significantly increased the total hemocyte counts (THC), hemocyanin content, total antioxidant capacity (T-AOC), acid phosphatase (ACP), and glutathione peroxidase activity (GSH-Px), whereas the immune-related parameters were significantly decreased in eyestalk-ablated crabs (P < 0.05). Therefore, these findings indicate that melatonin exerts a protective effect on organism injury, which could promote limb regeneration by up-regulating the expression of growth-related genes, improve digestive enzyme activity, and strengthen the immune response, particularly antioxidant capacity.

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into hydrogen peroxide and then degrade the hydrogen peroxide product through GSH-Px to protect cells from oxidative damage (Holmblad and Söderhäll, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Melatonin Promotes Cheliped Regeneration, Digestive Enzyme Function, and Immunity Following Autotomy in the Chinese Mitten Crab, Eriocheir sinensis

Zhang

Yang

et al. 2018

Front. Physiol.

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“…When invertebrates are attacked by foreign pathogens, oxygen is released to enhance resistance to prevent infection with pathogens (27, 28). Therefore, the antioxidant system is an important immune defense system for crustaceans.…”

Section: Discussionmentioning

confidence: 99%

“…Various antioxidant enzymes, oxidases and hydrolases play important roles before phagocytosis, during phagocytosis, and after phagocytosis. In crustaceans, the production of ROS is an important indicator of cell defense (27). ROS is indispensable for normal cell functions (such as redox signals and anti-pathogens), but excessive ROS can cause oxidative damage to tissues, such as oxidative damage of DNA, cell membranes, proteins, and enzymes (49).…”

Section: Discussionmentioning

confidence: 99%

“…In invertebrates, hemocyte phagocytosis is widely used to assess their antibacterial ability (26). When invertebrates are attacked by pathogens, oxygen free radicals are released to enhance their antibacterial ability (27). In addition, hemocytes can adhere to pathogens, trigger phagocytosis, and produce highly toxic reactive oxygen species (ROS) (28).…”

Section: Introductionmentioning

confidence: 99%

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Dietary L-Tryptophan Modulates the Hematological Immune and Antibacterial Ability of the Chinese Mitten Crab, Eriocheir sinensis, Under Cheliped Autotomy Stress

Zhang

Song

et al. 2018

Front. Immunol.

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In pond cultures of juvenile Eriocheir sinensis, limb autotomy stress seriously affects and restricts the quality and economic benefits of aquaculture. This study was designed to evaluate the effects of dietary supplementation of L-tryptophan on E. sinensis under the cheliped autotomy stress. In the present study, 252 crabs were divided into four groups: dietary L-trp supplementation with 0.28, 0.40, 0.53, and 0.70%, and their hematological immunity, antioxidant capacity, anti-stress, and antibacterial ability were evaluated after 14 days of using biochemical analysis, flow cytometry, and molecular biology techniques. First, we counted the mortality after 14 days of feeding and found that compared with other treatments, dietary supplementation of 0.53 and 0.70% L-trp significantly lowered the mortality of E. sinensis. Moreover, the total hemocyte count (THC), hemocyanin, and glutathione (GSH) content, and glutathione peroxidase (GSH-Px) activity significantly increased at 7 and 14 d with dietary supplementation of 0.53 and 0.70% L-trp, in contrast with the significant decrease in malondialdehyde (MDA) content at 14 d in the same dietary groups (P<0.05). Next, the bacterial challenge test after 14 days of feeding showed that the THC levels, phagocytic rate, and acid phosphatase (ACP) and alkaline phosphatase (ALP) activity were significantly higher with dietary supplementation of 0.53 and 0.70% L-trp after 12 and 24 h of Aeromonas hydrophila injection, along with a significant improvement in the antioxidant capacity (P<0.05). Further, we measured the expression of antibacterial-related protein genes (EslecB and HSP 90) and found that they were significant up-regulated in the hepatopancreas, hemocytes, intestine, and gill in the groups with dietary supplementation of 0.53% and 0.70% L-trp after 12 h or 24 h of A. hydrophila injection (P<0.05). Taken together, the observations in this study indicate that dietary supplementation of L-trp can enhance the antioxidant capacity and improve the hematological immune status and antibacterial ability of E. sinensis under the cheliped autotomy stress, thereby increasing the survival rate of E. sinensis under cheliped autotomy stress.

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“…In the last few decades, investigation of the effectiveness of the application of herbal medicines as immunomodulators in aquaculture has been conducted to reduce the use of chemicals and antibiotics during production ( 105 , 106 ). In fact, herbal medicine or plant extracts are rich in various biologically active substances with beneficial health properties, such as saponins, alkaloids, waxes, carotenoids, vitamin, terpenoids, tannic acid, organic acids, volatile oils, polysaccharides, glycosides, flavonoids, and others, are considered to benefit aquatic animals with improved growth and immune performance ( 107 – 110 ).…”

Section: Orally Administered Immunoprophylactics and The Implication In The Gut Immune Systemmentioning

confidence: 99%

Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

et al. 2021

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The gastrointestinal immune system plays an important role in immune homeostasis regulation. It regulates the symbiotic host-microbiome interactions by training and developing the host’s innate and adaptive immunity. This interaction plays a vital role in host defence mechanisms and at the same time, balancing the endogenous perturbations of the host immune homeostasis. The fish gastrointestinal immune system is armed with intricate diffused gut-associated lymphoid tissues (GALTs) that establish tolerance toward the enormous commensal gut microbiome while preserving immune responses against the intrusion of enteric pathogens. A comprehensive understanding of the intestinal immune system is a prerequisite for developing an oral vaccine and immunostimulants in aquaculture, particularly in cultured fish species. In this review, we outline the remarkable features of gut immunity and the essential components of gut-associated lymphoid tissue. The mechanistic principles underlying the antigen absorption and uptake through the intestinal epithelial, and the subsequent immune activation through a series of molecular events are reviewed. The emphasis is on the significance of gut immunity in oral administration of immunoprophylactics, and the different potential adjuvants that circumvent intestinal immune tolerance. Comprehension of the intestinal immune system is pivotal for developing effective fish vaccines that can be delivered orally, which is less labour-intensive and could improve fish health and facilitate disease management in the aquaculture industry.

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Effects of traditional medical herbs “minor bupleurum decoction” on the non-specific immune responses of white shrimp ( Litopenaeus vannamei )

Cited by 41 publications

References 40 publications

Melatonin Promotes Cheliped Regeneration, Digestive Enzyme Function, and Immunity Following Autotomy in the Chinese Mitten Crab, Eriocheir sinensis

Melatonin Promotes Cheliped Regeneration, Digestive Enzyme Function, and Immunity Following Autotomy in the Chinese Mitten Crab, Eriocheir sinensis

Dietary L-Tryptophan Modulates the Hematological Immune and Antibacterial Ability of the Chinese Mitten Crab, Eriocheir sinensis, Under Cheliped Autotomy Stress

Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture

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