Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin

Hasegawa, Takaaki; Yamaki, Kenichi; Muraoka, Isao; Nadai, Masayuki; Takagi, Kenzo; Nabeshima, Toshitaka

doi:10.1128/aac.39.9.2135

Cited by 13 publications

(14 citation statements)

References 14 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bioavailability of ampicillin, but not amoxicillin, was reduced significantly during a khat (Catha edulis)-chewing session (Fugh-Berman and Ernst, 2001). The pharmacokinetics of a single oral dose of ofloxacin were unaltered by either Sho-saiko-To or Rikkunshi-to (Hasegawa et al, 1995).…”

Section: H Other Herb -Drug Interactionsmentioning

confidence: 86%

Interactions of Herbs with Cytochrome P450

Zhou

Gao²,

Jiang

et al. 2003

Drug Metabolism Reviews

354

207

View full text Add to dashboard Cite

A resurgence in the use of medical herbs in the Western world, and the co-use of modern and traditional therapies is becoming more common. Thus there is the potential for both pharmacokinetic and pharmacodynamic herb-drug interactions. For example, systems such as the cytochrome P450 (CYP) may be particularly vulnerable to modulation by the multiple active constituents of herbs, as it is well known that the CYPs are subject to induction and inhibition by exposure to a wide variety of xenobiotics. Using in vitro, in silico, and in vivo approaches, many herbs and natural compounds isolated from herbs have been identified as substrates, inhibitors, and/or inducers of various CYP enzymes. For example, St. John's wort is a potent inducer of CYP3A4, which is mediated by activating the orphan pregnane X receptor. It also contains ingredients that inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Many other common medicinal herbs also exhibited inducing or inhibiting effects on the CYP system, with the latter being competitive, noncompetitive, or mechanism-based. It appears that the regulation of CYPs by herbal products is complex, depending on the herb type, their administration dose and route, the target organ and species. Due to the difficulties in identifying the active constituents responsible for the modulation of CYP enzymes, prediction of herb -drug metabolic interactions is difficult. However, herb-CYP interactions may have important clinical and toxicological consequences. For example, induction of CYP3A4 by St. John's wort may partly provide an explanation for the enhanced plasma clearance of a number of drugs, such as cyclosporine and innadivir, which are known substrates of CYP3A4, although other mechanisms including modulation of gastric absorption and drug transporters cannot be ruled out. In contrast, many organosulfur compounds, such as diallyl sulfide from garlic, are potent inhibitors of CYP2E1; this may provide an explanation for garlic's chemoproventive effects, as many mutagens require activation by CYP2E1. Therefore, known or potential herb -CYP interactions exist, and further studies on their clinical and toxicological roles are warranted. Given that increasing numbers of people are exposed to a number of herbal preparations that contain many constituents with potential of CYP modulation, high-throughput screening assays should be developed to explore herb-CYP interactions.Key Words: Herb; Cytochrome P450; Drug interactions.Abbreviations: Ah, aryl hydrocarbon; AUC, the area of the plasma concentrationtime curve; B[a]P, benzo[a]pyrene; C max , the maximum plasma concentration; CL int , intrinsic clearance; CYP, cytochrome P450; DAD, diallyl disulfide; DAS, diallyl sulfide; DASO, diallyl sulfoxide; DASO 2 , diallyl sulfone; DPS, dipropyl sulfide; DPDS, dipropyl disulfide; K i , inhibition constant; K m , Michaelis -Menten constant; NADPH, nicotinamide adenine dinucleotide phosphate; NNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; N-PiP, N-nitrosopiperidine; PgP, P-glycoprotein; PhIP...

show abstract

Section: H Other Herb -Drug Interactionsmentioning

confidence: 86%

Interactions of Herbs with Cytochrome P450

Zhou

Gao²,

Jiang

et al. 2003

Drug Metabolism Reviews

354

207

View full text Add to dashboard Cite

show abstract

“…Blood samples (approximately 1 ml) were collected with a vacuum blood collection tube containing EDTA (Venoject II, Terumo, Tokyo, Japan) at time zero (just before the start of administration) and at 0.5, 1, 1.5, 2, 3, 4, 8, 12, and 24 h for ciprofloxacin and at 1,2,3,4,6,8,12, and 24 h for tetracycline after each dose. Blood samples were immediately centrifuged to yield plasma.…”

Section: Methodsmentioning

confidence: 99%

“…We have previously reported that the Kampo preparations, Hotyu-ekki-to, Rikkunshi-to and Juzen-taiho-to, have no effect on the pharmacokinetics of the quinolone antimicrobial agent levofloxacin in healthy volunteers. 6) To our knowledge, there is no information regarding pharmacokinetic interaction between byakkokaninjinto, which contains a relatively large amount of cationic metals, and antimicrobial agents. However, the therapy with the Kampo preparation is a common practice and is sometimes prescribed without doctors' knowledge of whether or not pharmacokinetic interactions between the Kampo preparation and Western drugs including antimicrobial agents occur.…”

mentioning

confidence: 99%

Effect of a Kampo Preparation, Byakkokaninjinto, on Pharmacokinetics of Ciprofloxacin and Tetracycline

Ohnishi

Hitoshi

Katoh

et al. 2009

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

“…Many herb-Western medicines or Kampo medicinesWestern medicines interactions have been discussed before [2][3][4][5][6]. Coadministration of St. John's wort, a herb extensively used as an antidepressant [7], potently inhibited the activities of major human drug-metabolizing enzymes [8].…”

Section: Introductionmentioning

confidence: 99%