Effect of a Kampo Preparation, Byakkokaninjinto, on Pharmacokinetics of Ciprofloxacin and Tetracycline

Ohnishi, Masafumi; Hitoshi, Kotaro; Katoh, Miki; Nadai, Masayuki; Abe, Fumie; Kurono, Shunsuke; Saito, Hiroko; Haniuda, Masayuki; Hasegawa, Takaaki

doi:10.1248/bpb.32.1080

Cited by 9 publications

(10 citation statements)

References 28 publications

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“…In the first place, G. kola is known to contain flavonoids [14] which have functional groups that may favour complex formation with some compounds [15]. Secondly, G. kola also contains trace elements or minerals such as calcium, aluminum, magnesium, potassium, sodium, zinc and copper [16], some of which are known to cause drug interactions through chelate formation [8,17]. It is known that quinine may also act as a ligand by forming a stable five-membered ring with some metals through the quinuclidinic nitrogen and the hydroxyl oxygen, or by binding through the quinolinic aromatic nitrogen [18].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have reported that G. kola reduced ciprofloxacin absorption in vitro [6], and reduced both the C max and AUC when co-administered with ofloxacin in humans [4,5]. Some authors have also reported a herb -drug interaction in which a Kampo preparation which contains various herbal medicines and metal cations such as calcium, magnesium and aluminum caused significant reduction in plasma tetracycline and ciprofloxacin concentrations in healthy volunteers through complex formation [8,9]. A significant pharmacokinetic interaction between quinine (an antimalarial medicine) and G. kola in healthy volunteers has earlier been reported and the results were suggestive of interference with quinine absorption since parameters indicative of interference with elimination were not significantly altered [7].…”

Section: Introductionmentioning

confidence: 99%

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In vitro study of interaction between quinine and Garcinia kola

Igbinoba¹,

Adehin²,

Onyeji³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro study of interaction between quinine and Garcinia kola

Igbinoba¹,

Adehin²,

Onyeji³

et al. 2016

Trop. J. Pharm Res

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Section: )mentioning

confidence: 99%

“…The possibilities of interaction between Kampo medicines and Western drugs in experimental studies have been reported in recent years. [14][15][16][17] Combinational use of Kampo medicines and antibiotics was observed in 7% of cases of Kampo prescription.18) Because most glycosides are transformed by intestinal bacteria before being absorbed into the body, 19,20) the metabolism of available glycosides in Kampo medicine administered orally may be influenced by antibiotics.21-23) Therefore, it is clinically important to evaluate whether Kampo medicine has drug interactions with antibiotics. In this study, we also investigated whether eight antibiotics (ampicillin, kanamycin, fosfomycin, cefcapene pivoxil, clarithromycin, levofloxacin, minocycline, and faropenem) actually affect the purgative action of sennoside A in mice.…”

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The Influence of Glycyrrhiza and Antibiotics on the Purgative Action of Sennoside A from Daiokanzoto in Mice

Matsui

Takayama

Sato

et al. 2011

Biological & Pharmaceutical Bulletin

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Kampo medicine is Japanese traditional medicine originating from ancient China. It is produced by combining multiple crude drugs and includes many constituents. This makes it extremely difficult to identify the active constituents and to reveal the mechanism of the pharmacological action. An exception to this is daiokanzoto (DKT), a simple formulation that consists of two kinds of crude drugs, Rhei Rhizoma (rhubarb) and Glycyrrhizae Radix (glycyrrhiza). It is the most well-known Kampo medicine and was demonstrated to be applicable for constipation in a clinical double-blind study.1) The purgative effect of DKT is due to rhubarb, which is considered to promote the secretion of water and electrolytes into the colon and bowel movement.2) Sennoside A, which is a well-known diarrheal constituent of rhubarb, is an inactive glycoside, and is transformed to an active metabolite, rheinanthrone, by intestinal bacteria.3-5) Therefore, investigation of the purgative action and metabolism of sennoside A is important in order to understand the character of DKT.Glycyrrhiza is a crude drug contained in more than 70% of Kampo medicines certified by the Japanese Ministry of Health and Welfare. 6) Unlike rhubarb, glycyrrhiza does not induce diarrhea directly. Glycyrrhiza has been considered to moderate the effects of other crude drugs in Kampo medicine. In DKT, glycyrrhizin and liquiritin, the main constituents of glycyrrhiza, cooperatively prevent the rhubarb-induced strong spiking activity of colonic circular muscle.7) Interestingly, it has been reported that glycyrrhiza shows a significant potentiating effect on the purgative action of rhubarb in rats when DKT is prepared at a ratio (4 : 1) of rhubarb to glycyrrhiza that is used for the traditional formulation. 8)However, it is not clear how glycyrrhiza potentiates the purgative action of rhubarb. Recently, we found that the activity of sennoside A metabolism in intestinal bacteria was significantly accelerated when glycyrrhiza, liquiritin, or liquiritin apioside coexisted with sennoside A. 9) In this study, we investigated whether glycyrrhiza, liquiritin, or liquiritin apioside actually potentiates the purgative action of sennoside A in mice. Since the bioavailability of felodipine was shown to be improved with grapefruit juice in a clinical study, 10) a number of the studies have been published on interactions between Western drugs and herbal medicines as medicinal topics.11,12) Kampo medicine is clinically used for the treatment of a wide variety of diseases in Japan. Since 86.3% of physicians have been reported to use Kampo medicines in Japan, 13) Kampo medicines are frequently prescribed with Western drugs for the treatment of various chronic diseases. The possibilities of interaction between Kampo medicines and Western drugs in experimental studies have been reported in recent years. [14][15][16][17] Combinational use of Kampo medicines and antibiotics was observed in 7% of cases of Kampo prescription.18) Because most glycosides are transformed by intestinal bacteria befo...

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