Effects of total sleep deprivation in major depression: Overnight improvement of mood is accompanied by increased pain sensitivity and augmented pain complaints

Kundermann, Bernd; Hemmeter-Spernal, Julia; Huber, MT; Krieg, J.‐C.; Lautenbacher, S.

doi:10.1055/s-2007-991710

Cited by 15 publications

(27 citation statements)

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“…Other studies have also found that sleep restriction may affect thermal pain thresholds (Kundermann et al, 2008(Kundermann et al, , 2004Schuh-Hofer et al, 2013). Furthermore, Roehrs et al (2012) have found extended Table 3 Laser evoked potential (LEP) N2P2 amplitude at baseline (Day 1) and after intervention (Day 3) in the sleep restricted (4 h) and unrestricted (9 h Repeated measures ANOVA (no transformation), F-statistic (df 1,31) and p-value.…”

Section: Discussionmentioning

confidence: 90%

“…Although a nociceptive effect of sleep restriction was demonstrated in an experimental study as early as 1934 (Cooperman et al, 1934), there are still uncertainties about the nature of this relationship (Azevedo et al, 2011;Haack and Mullington, 2005;Kundermann et al, 2008Kundermann et al, , 2004Onen et al, 2001;Roehrs et al, 2006;Schuh-Hofer et al, 2013;Smith et al, 2007Smith et al, , 2005Tiede et al, 2010). From previous studies it seems that sleep restriction enhances our subjective experience of pain, including reduced pain thresholds, but reduce the brain's reaction to pain as demonstrated by laser evoked potential (LEP) amplitudes (Azevedo et al, 2011;Tiede et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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The effect of sleep restriction on laser evoked potentials, thermal sensory and pain thresholds and suprathreshold pain in healthy subjects

Ødegård¹,

Omland²,

Nilsen³

et al. 2015

Clinical Neurophysiology

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The effect of sleep restriction on laser evoked potentials, thermal sensory and pain thresholds and suprathreshold pain in healthy subjects

Ødegård¹,

Omland²,

Nilsen³

et al. 2015

Clinical Neurophysiology

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“…Somatosensory thresholds usually do not change after total sleep deprivation in healthy volunteers [548,549,558] or patients with chronic pain [552,559]. Nonetheless, healthy subjects perceived heat stimuli as more painful after sleep restriction compared to unrestricted sleep [548,553,560].…”

Section: The Role Of Sleep In Painmentioning

confidence: 99%

Fibromyalgia: A Critical and Comprehensive Review

Borchers

Gershwin

2015

Clinic Rev Allerg Immunol

215

217

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Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise classification. It is often considered as part of the global overview of functional somatic syndromes that are otherwise medically unexplained or part of a somatization disorder. Patients with fibromyalgia share symptoms with other functional somatic problems, including issues of myalgias, arthralgias, fatigue and sleep disturbances. Indeed, there is often diagnostic and classification overlap for the case definitions of a variety of somatization disorders. Fibromyalgia, however, is a critically important syndrome for physicians and scientists to be aware of. Patients should be taken very seriously and provided optimal care. Although inflammatory, infectious, and autoimmune disorders have all been ascribed to be etiological events in the development of fibromyalgia, there is very little data to support such a thesis. Many of these disorders are associated with depression and anxiety and may even be part of what has been sometimes called affected spectrum disorders. There is no evidence that physical trauma, i.e., automobile accidents, is associated with the development or exacerbation of fibromyalgia. Treatment should be placed on education, patient support, physical therapy, nutrition, and exercise, including the use of drugs that are approved for the treatment of fibromyalgia. Treatment should not include opiates and patients should not become poly pharmacies in which the treatment itself can lead to significant morbidities. Patients with fibromyalgia are living and not dying of this disorder and positive outlooks and family support are key elements in the management of patients.

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“…IL1 and TNF are pleiotropic, serving both physiological and pathological functions including modulation of memory, mood, inflammation and sleep. Sleep loss and altered cytokine levels are associated with enhanced sensitivity to pain 12,13 and kindling stimuli, 14 fatigue, [15][16][17] sleepiness and rebound sleep, metabolic syndrome 18,19 including type-2 diabetes, 20 and impaired cognition 21,22 and memory. [23][24][25] These sleep loss-associated symptoms can be elicited by injections of TNF or IL1.…”

Section: Sleep Regulatory Substance Criteriamentioning

confidence: 99%