Biochemical Regulation of Sleep and Sleep Biomarkers

Clinton, James M.; Davis, Christopher J.; Zielinski, Mark R.; Jewett, Kathryn A.; Krueger, James M.

doi:10.5664/jcsm.1360

Cited by 132 publications

(121 citation statements)

References 57 publications

(60 reference statements)

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“…Although recognizing the oversimplification, 42 we argue that endogenous molecules can be categorized as primarily wake-promoting/sleep-suppressing (eg, catecholamines, orexin, and histamine) and sleep-promoting/wakesuppressing substances (eg, g -aminobutyric acid [GABA], adenosine, serotonin, melatonin, prostaglandin D2). 43 Very few molecular studies have been conducted in insomnia and have focused on only a limited set of molecules (eg, cortisol and GABA).…”

Section: Molecular Mechanisms Of Sleep and Insomniamentioning

confidence: 99%

The Pathophysiology of Insomnia

Levenson

Kay

Buysse

2015

Chest

280

147

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Insomnia disorder is characterized by chronic dissatisfaction with sleep quantity or quality that is associated with diffi culty falling asleep, frequent nighttime awakenings with diffi culty returning to sleep, and/or awakening earlier in the morning than desired. Although progress has been made in our understanding of the nature, etiology, and pathophysiology of insomnia, there is still no universally accepted model. Greater understanding of the pathophysiology of insomnia may provide important information regarding how, and under what conditions, the disorder develops and is maintained as well as potential targets for prevention and treatment.The aims of this report are (1) to summarize current knowledge on the pathophysiology of insomnia and (2) to present a model of the pathophysiology of insomnia that considers evidence from various domains of research. Working within several models of insomnia, evidence for the pathophysiology of the disorder is presented across levels of analysis, from genetic to molecular and cellular mechanisms, neural circuitry, physiologic mechanisms, sleep behavior, and self-report. We discuss the role of hyperarousal as an overarching theme that guides our conceptualization of insomnia. Finally, we propose a model of the pathophysiology of insomnia that integrates the various types of evidence presented.

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Section: Molecular Mechanisms Of Sleep and Insomniamentioning

confidence: 99%

The Pathophysiology of Insomnia

Levenson

Kay

Buysse

2015

Chest

280

147

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“…Animals lacking receptors for the cytokines demonstrate less sleep. 69 Compounds known to inhibit NREM sleep, such as corticotropin-releasing hormone, glucocorticoids, and prostaglandin E 2 , also suppress the production of IL-1 or TNF. 70 Other substances known to inhibit either IL-1 b or TNF-a include IL-4, IL-10, IL-13, and transforming factor growth factor-b , and they also inhibit NREM sleep.…”

Section: Sleep and The Immune Systemmentioning

confidence: 99%

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

Parish

2013

Chest

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“…[17][18][19][20] TNF also plays an essential beneficial role in a variety of physiological functions including immune surveillance, sleep regulation, synaptic scaling, and neurogenesis. [33][34][35][36][37][38] TNF was initially recognized for its ability to kill tumor cells without harming normal cells. 11 In addition to confirming this antitumor capacity, [12][13][14] early studies also reported that TNF was essential in anti-infection.…”

Section: Discussionmentioning

confidence: 99%

The Physiological Role of Tumor Necrosis Factor in Human Immunity and Its Potential Implications in Spinal Manipulative Therapy: A Narrative Literature Review

Zhang

Yao

2016

Journal of Chiropractic Medicine

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Objective: Although tumor necrosis factor (TNF) is a well-known inflammatory cytokine in the pathological development of various human diseases, its physiological roles are not widely understood nor appreciated. The molecular mechanisms underlying spinal manipulation therapy (SMT) remain elusive. The relationship between TNF and SMT is unclear. Thus, we performed this literature review to better understand TNF physiology and its potential relationship with SMT, and we propose a novel mechanism by which SMT may achieve clinical benefits by using certain beneficial features of TNF. Methods: We searched several databases for relevant articles published between 1975 and 2015 and then reexamined the studies from current immunophysiological perspectives. Results: The history and recent progresses in TNF physiology research were explored. Conflicting reports on the relationship between TNF and SMT were identified. Based on the newly discovered interaction between TNF and regulatory T cells, we proposed a putative biphasic TNF response to SMT, which may resolve the conflicts in the reported observations and interpretations. Conclusion: The current literature about TNF informed our discussion of new physiological roles for TNF, which may help to better understand the physiological effects of SMT. (J Chiropr Med 2016;15:190-196)

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Biochemical Regulation of Sleep and Sleep Biomarkers

Cited by 132 publications

References 57 publications

The Pathophysiology of Insomnia

The Pathophysiology of Insomnia

Genetic and Immunologic Aspects of Sleep and Sleep Disorders

The Physiological Role of Tumor Necrosis Factor in Human Immunity and Its Potential Implications in Spinal Manipulative Therapy: A Narrative Literature Review

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