Effects of topical application of patchouli alcohol on the UV-induced skin photoaging in mice

Feng, Xue-Xuan; Yu, Xiu-Ting; Li, Wenjie; Kong, Songzhi; Liu, Yuhong; Xie, Zhaoxiong; Xian, Yan‐Fang; Zhang, Xiaojun; Su, Zi‐Ren; Lin, Zhi‐Xiu

doi:10.1016/j.ejps.2014.07.001

Cited by 60 publications

(38 citation statements)

References 56 publications

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“…The inhibitory action of OFIE on TNFa signaling may be beneficial in therapeutic interventions for various skin diseases, such as psoriasis and photoaging, in which TNFa plays a critical role. 21,22 Various ligands are known to activate the NRF2-NQO1 battery. Ketoconazole activates AHR and then upregulates NRF2-NQO1 expression.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

Nakahara

Mitoma

Hashimoto-Hachiya

et al. 2015

Journal of Medicinal Food

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quinone oxidoreductase 1 (NQO1), which inhibited the generation of reactive oxygen species in keratinocytes challenged with tumor necrosis factor α or benzo[α]pyrene. The antioxidant capacity of OFIE was canceled in NRF2 knockdown keratinocytes. OFIE exerted this NRF2-NQO1 upregulation through activation of the aryl hydrocarbon receptor (AHR). Moreover, the ligation of AHR by OFIE upregulated the expression of epidermal barrier proteins: filaggrin and loricrin. OFIE also prevented TH2 cytokine-mediated downregulation of filaggrin and loricrin expression in an AHR-dependent manner because it was canceled in AHR knockdown keratinocytes. Antioxidant OFIE is a potent activator of AHR-NRF2-NQO1 signaling and may be beneficial in treating barrier-disrupted skin disorders.

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Section: Discussionmentioning

confidence: 99%

Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

Nakahara

Mitoma

Hashimoto-Hachiya

et al. 2015

Journal of Medicinal Food

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“…Despite its wide applications in flavouring, Pogostemonis Herba, which is rich in PA, possesses protective pharmacological activity 11 . Our previous study reported that PA has a gastroprotective effect against experimental gastric injury, but the gastric metabolism of PA and the anti-ulcer properties of its metabolite remained unclear.…”

Section: Discussionmentioning

confidence: 99%

Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Liu

Liang

et al. 2017

Sci Rep

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Pogostemonis Herba is a functional food approved in Asian countries. Its major constituent, patchouli alcohol (PA), possesses a gastroprotective effect and is reported to transform into β-patchoulene (β-PAE) under acidic conditions. To investigate whether β-PAE, the metabolite of PA, has a protective effect on the gastrointestinal tract, the formation of β-PAE by gastric juice and the anti-ulcerogenic potential of β-PAE against ethanol-induced gastric injury were evaluated. The Results indicated that PA was converted to β-PAE by rat gastric juice. Additionally, β-PAE was significantly better than PA at reducing the area of gastric ulcer. The overproduction of malondialdehyde, tumour necrosis factor-α, interleukin (IL)-1β, IL-6, Fas, FasL and caspase-3 was markedly inhibited by β-PAE while the underproduction of superoxide dismutase, glutathione and catalase was significantly improved. β-PAE also regulated the NF-κB and ERK1/2 signalling pathways. Our findings suggest that β-PAE has potential therapeutic efficacy for antiulcer treatment.

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“…The application of antioxidants to the skin surface protects the skin from oxidative damage and photodamage for a long time [19,20,21]. Many plant antioxidants also exhibit antiinflammatory activity and can be used to alleviate oxidative stress-induced damage, such as photodamage and skin cancer [22,23,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

Huang

Yin

et al. 2017

IJMS

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Coffea arabica extract (CAE) containing 48.3 ± 0.4 mg/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB/c hairless mice. The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46.4%, and hydroxyl radical scavenging activity of 20.3%. The CAE dose dependently reduced UVB-induced reactive oxygen species (ROS) generation in fibroblasts. Furthermore, CAE inhibited the UVB-induced expression of cyclooxygenase-2 and p-inhibitor κB, and the translocation of nuclear factor-kappa B (NF-κB) to the nucleus of fibroblasts. In addition, CAE alleviated UVB-induced photoaging and photodamage in BALB/c hairless mice by restoring the collagen content and reduced UVB-induced epidermal hyperplasia. CAE also inhibited UVB-induced NF-κB, interleukin-6, and matrix metalloproteinase-1 expression in the hairless mouse skin. The results indicated that CAE exhibits antiphotodamage activity by inhibiting UV-induced oxidative stress and inflammation. Therefore, CAE is a candidate for use in antioxidant, antiinflammatory, and antiphotodamage products.

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Effects of topical application of patchouli alcohol on the UV-induced skin photoaging in mice

Cited by 60 publications

References 56 publications

Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes

Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury

Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin

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