Effects of Tissue Plasminogen Activator for Acute Ischemic Stroke at One Year

Abstract

During 12 months of follow-up, the patients with acute ischemic stroke who were treated with t-PA within three hours after the onset of symptoms were more likely to have minimal or no disability, than the patients given placebo. These results indicate a sustained benefit of t-PA for such patients.

Cognitive and functional outcome after intravenous recombinant tissue plasminogen activator treatment in patients with a first symptomatic brain infarct

“…Independence in these activities enables the stroke patient to be discharged home without being too dependent on others. With respect to basic functional outcome, our findings replicate and extend a previous study on the benefit of rt-PA at 6 and 12 months post-stroke [3].…”

“…Similar treatment effects have been found after six months and one year poststroke [3]. The benefit of rt-PA is thought to be due to the early recanalisation of occluded arteries, resulting in increased cerebral reperfusion [4] and a subsequent reduction of lesion volume [5].…”

“…NIHSS, median (range) 5 (2-17) 11 (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) Values are means ± standard deviations unless otherwise indicated. * High education = 5 (high school education) to 7 (university degree)…”

“…■ Key words thrombolysis · acute stroke · cognition · functional outcome while it has been shown that patients treated with rt-PA have a favourable outcome with respect to basic activities of daily life (bADL) [1][2][3],it is unknown whether this also applies to more complex activities that are necessary for independence at home (instrumental ADL: iADL).…”

Predictors of functional outcome after right hemisphere stroke in patients with or without thrombolytic treatment

“…The results of our study group have also indicated that thrombolysis has a favorable effect on visuoperceptual functions in acute RH stroke (Laihosalo et al, forthcoming). Several other studies also suggest that thrombolysis improves the functional outcome of stroke patients concerning basic activities of daily living (ADL) (Kwiatkowski et al, 1999;Lindsberg et al, 2003;Lansberg, Schrooten, Bluhmki, Thijs, & Saver, 2009; The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group, 2 LOSOI ET AL. 1995), which include activities like feeding, dressing, bathing, and toileting (Kelly-Hayes, Robertson, Broderick, Duncan, & Hershey, 1998).…”