Cognitive and functional outcome after intravenous recombinant tissue plasminogen activator treatment in patients with a first symptomatic brain infarct

Predictors of functional outcome after right hemisphere stroke in patients with or without thrombolytic treatment

“…Considering those results, it can be hypothesized that our IADL functional outcome measure (FAI) was not sensitive enough to separate the functional outcome of this patient group although in basic ADL functions measured by hospitalization time significant connection to thrombolysis was found. Downloaded by [Tampere University Our finding about thrombolysis not being a statistically significant predictor of functional outcome does not corroborate the study by Nys et al (2006), which included both RH and LH stroke patients, whereas our study focused on RH stroke patients. This has to also be considered when interpreting the clinical significance of our results.…”

“…Our finding about thrombolysis not being a statistically significant predictor of instrumental functional outcome (IADL), although it has been shown to be a significant predictor of earlier discharge to home in patients with moderate/severe RH infarct (Ruuskanen et al, 2010), suggests that also in future studies functional outcome should be evaluated taking into account both ADL and IADL outcome. Since our findings differ from those of Nys et al (2006), further research is needed with larger RH and LH stroke patient groups.…”

“…The study also aimed to ascertain how neuropsychological symptoms in the acute phase predict functional outcome at 6-month followup. Thrombolysis has previously been reported to improve the ADL outcome of stroke patients (Kwiatkowski et al, 1999;Lansberg et al, 2009;Lindsberg et al, 2003;Nys et al, 2006). However, the association of thrombolytic treatment and neuropsychological symptoms with IADL outcome of stroke patients has not been widely researched.…”

“…The association of thrombolytic treatment and neuropsychological symptoms with IADL outcome of stroke patients has not been widely researched. In the only study to date on that by Nys, van Zandvoort, Algra, Kappelle, and de Haan (2006) it was found that in 92 patients with first-ever symptomatic stroke thrombolytic treatment was associated with favorable ADL and IADL outcome at 6-month follow-up but not with better cognitive abilities. Their study included both RH and left hemisphere (LH) patients.…”

Rightward bias in right hemisphere infarct patients with or without thrombolytic treatment and in healthy controls

“…The results suggest that thrombolytic treatment is related to a favorable effect on visuoperceptual functions in acute phase of stroke (Laihosalo et al, forthcoming). Nys et al (2006) have suggested that thrombolytic treatment after RH infarct is associated with a favorable outcome in activities of daily living, but not in different cognitive functions during a 6-10-month follow-up.…”