Effects of TIPS on Liver Perfusion Measured by Dynamic CT

Abstract

In patients with cirrhosis, the hepatic arterial perfusion increased, whereas portal venous and total perfusion decreased compared with that of healthy volunteers. TIPS placement caused a statistically significant increase of the hepatic arterial and total hepatic perfusion. The portal venous parenchymal perfusion remained unchanged.

Arterial and portal venous liver perfusion using selective spin labelling MRI

“…The postprandial arterial perfusion we found is in line with the other studies, especially with [24], concerning 24 control subjects. The preprandial arterial perfusion is slightly higher than that from the studies using CE-MRI and CE-CT.…”

“…a mean of 102 ml/100ml/min in [24] (CE-CT, unknown prandial status) and a mean of 126.3 ml/100g/min in [25] (CE-MRI, preprandial status). The preprandial portal perfusion we found is lower than the literature values, although the PVSL-based perfusion change correlated well with the flow-based perfusion change (r 2 =0.77).…”

Clinical application of hepatic CT perfusion

“…CTP can detect the abnormality of liver perfusion before morphologic change occurs. Fournier et al [14] induced primary hepatic carcinoma in a rat model by chemistry, and performed CTP after 11 and 18 wk, respectively, showing that the induced hepatic carcinoma has a high arterial blood flow and a low portal blood flow, with a sensitivity of 87% and a specificity of 80% at week 18, a sensitivity of 86% and a specificity of 65% at week [3] 0.19 1 0.93 2 Weidekamm et al [4] (24) 0.2 ± 0.08 1.02 ± 0.35 Zhou et al [5] (4) 0.17 ± 0.08 0.9 ± 0.04 16 ± 16% 106.24 ± 54.53 20.24 ± 8.26 15.06 ± 8.94 Hashimoto et al [6] (10) 18.4 ± 5.6% 103.9 ± 18 12.5 ± 2.0 11.1 ± 1. [7] Rat 14…”

The evaluation of haemodynamics in cirrhotic patients with spectral CT

“…The liver perfusion condition is informative for patient management and evaluation of progress [3,4]. The HPI, which is the ratio of hepatic arterial perfusion to that of total perfusion, is one of the most commonly obtained hepatic CT perfusion parameters [17].…”

“…At present, a CT liver perfusion scan is one of the imaging means to obtain liver haemodynamics. Perfusion parameters, such as liver blood volume, blood flow (BF), mean transit time (MTT) and hepatic perfusion index (HPI), can be obtained by perfusion scans using the cine mode or dynamic shuttle mode and mathematic calculations [2][3][4]. Liver haemodynamic changes in cirrhotic patients with portal hypertension can be detected by calculating the liver perfusion parameters, including decreasing liver BF and increasing liver HPI, that are related to decreased liver function [1,5].…”