The evaluation of haemodynamics in cirrhotic patients with spectral CT

Lq, Zhao; He, Wei; Yan, Bo; Hy, Wang; Wang, J

doi:10.1259/bjr.20130228

Cited by 17 publications

(6 citation statements)

References 21 publications

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“…In a study using dual energy or spectral CT, the combination of normalized iodine concentration and iodine concentration ratio showed high sensitivity and specificity for differentiating healthy liver from cirrhotic liver, especially in Class C cirrhotic liver [165]. Another study on spectral CT showed that the arterial iodine fraction was statistically significantly different between a control group and patients with chronic liver disease Child-Pugh Grades A, B and C [166]. …”

Section: Ct Including Perfusion Fractional Extracellular Space and mentioning

confidence: 99%

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

et al. 2017

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Hepatic fibrosis is potentially reversible, however early diagnosis is necessary for treatment in order to halt progression to cirrhosis and development of complications including portal hypertension and hepatocellular carcinoma. Morphologic signs of cirrhosis on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) alone are unreliable and are seen with more advanced disease. Newer imaging techniques to diagnose liver fibrosis are reliable and accurate, and include magnetic resonance elastography and US elastography (1 dimensional transient elastography and point shear wave elastography or acoustic radiation force impulse imaging). Research is ongoing with multiple other techniques for the noninvasive diagnosis of hepatic fibrosis, including MRI with diffusion weighted imaging, hepatobiliary contrast enhancement, and perfusion; CT using perfusion, fractional extracellular space techniques, and dual energy, contrast-enhanced US, texture analysis in multiple modalities, quantitative mapping, and direct molecular imaging probes. Efforts to advance the noninvasive imaging assessment of hepatic fibrosis will facilitate earlier diagnosis and improved patient monitoring with the goal of preventing the progression to cirrhosis and its complications.

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Section: Ct Including Perfusion Fractional Extracellular Space and mentioning

confidence: 99%

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

et al. 2017

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“…The correlation coefficient between the NIC L and DPVP was significantly higher than that between the IC PV and DPVP. Previous studies demonstrated that ICs and NICs obtained at dual-energy CT provided high sensitivity and specificity for differentiating healthy liver from cirrhotic liver and had good correlation with Child–Pugh grades (14,33). Further investigation indicated the potentiality of ICs in quantitative analysis of cirrhotic hemodynamics (34).…”

Section: Discussionmentioning

confidence: 99%

“…Iodine maps generated from these material decomposition images can be used to examine tissue hemodynamics (13). Iodine concentrations (ICs) were shown to be a potentially useful parameter in hepatic hemodynamic surveillance and is closely correlated with the Child–Pugh grade (14). The aim of the present study was to assess the possibility of using ICs obtained from DESCT to estimate portal venous pressure in patients with cirrhosis and PTH.…”

Section: Introductionmentioning

confidence: 99%

The evaluation of portal hypertension in cirrhotic patients with spectral computed tomography

et al. 2022

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Background Iodine concentrations measured using dual-energy spectral CT (DESCT) have been recently proposed as providing good performance for examining tissues hemodynamics. Purpose To evaluate the diagnostic efficacy of DESCT-derived parameters in evaluating portal venous pressure in patients with liver cirrhosis. Material and Methods A total of 71 patients with liver cirrhosis who underwent percutaneous transhepatic portal vein puncture procedures were included in this study. All participants underwent DESCT and gastrointestinal endoscopy within one month before the operation. The direct portal venous pressure of each participant was measured preoperatively. Results Stepwise multivariate linear regression analysis showed that the iodine concentrations in the portal vein and hepatic parenchyma during the portal venous phase and the platelet count were independently correlated with the direct portal venous pressure ( P < 0.001, P < 0.001, and P = 0.030, respectively). Receiver operating characteristic analysis revealed that the normalized iodine concentration of the hepatic parenchyma had the best performance for identifying clinically significant portal hypertension (≥10 mmHg), esophageal varices, and high-risk esophageal varices (the area under the curve values were 0.951, 0.932, and 0.960, respectively). Conclusion The normalized iodine concentration of the hepatic parenchyma is a reliable parameter to non-invasively assess portal venous pressure in patients with liver cirrhosis.

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“…Several studies have shown good correlation between IC and NIC and histologic fibrosis and cirrhosis, although different scanning phases were used [89][90][91][92]. The ratio between IC at arterial and portal venous phases is another promising quantitative parameter [90,93]. Iodine slopes calculated from liver IC at the equilibrium phase, as well as either the arterial or portal venous phase, also correlate positively with the model for end-stage liver disease (MELD) score [94].…”

Section: Fibrosismentioning

confidence: 99%

Spectral CT: Current Liver Applications

2023

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Using two different energy levels, dual-energy computed tomography (DECT) allows for material differentiation, improves image quality and iodine conspicuity, and allows researchers the opportunity to determine iodine contrast and radiation dose reduction. Several commercialized platforms with different acquisition techniques are constantly being improved. Furthermore, DECT clinical applications and advantages are continually being reported in a wide range of diseases. We aimed to review the current applications of and challenges in using DECT in the treatment of liver diseases. The greater contrast provided by low-energy reconstructed images and the capability of iodine quantification have been mostly valuable for lesion detection and characterization, accurate staging, treatment response assessment, and thrombi characterization. Material decomposition techniques allow for the non-invasive quantification of fat/iron deposition and fibrosis. Reduced image quality with larger body sizes, cross-vendor and scanner variability, and long reconstruction time are among the limitations of DECT. Promising techniques for improving image quality with lower radiation dose include the deep learning imaging reconstruction method and novel spectral photon-counting computed tomography.

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The evaluation of haemodynamics in cirrhotic patients with spectral CT

Cited by 17 publications

References 21 publications

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

Evaluation of hepatic fibrosis: a review from the society of abdominal radiology disease focus panel

The evaluation of portal hypertension in cirrhotic patients with spectral computed tomography

Spectral CT: Current Liver Applications

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