Effects of time-restricted feeding and type of food on fertility competence in female mice

Konishi, Nafuko; Matsumoto, Hiroshi; Hashimoto, Shu; Gamage, Udayanga Sanath Kankanam; Tachibana, Daisuke; Fukuda, Aisaku; Morimoto, Yoshiharu; Koyama, Masayasu

doi:10.1038/s41598-022-11251-3

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…Circadian disruption induced by other factors including chronically jetlag or genetic ablation of circadian genes was restored in mice treated with TRF (Chaix et al, 2019). However, TRF impaired fertility competence, which might be attributed to decreased serum lipids and increased oxidative stress in oocytes in mice (Konishi et al, 2022).…”

Section: Circadian Disruption and Endocrine Fgf Dysregulationmentioning

confidence: 95%

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

Yang,

Zarbl,

Guo

2024

Mol Pharmacol

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ABBREVIATIONSFGF (fibroblast growth factor), BA (bile acid), SCN (suprachiasmatic nucleus), CG (clock gene), CCG (clock-controlled gene), BMAL1(brain and muscle Arnt-Like 1), CLOCK (circadian locomotor output cycles kaput), PER (period), CRY (cryptochrome), REV-ERB (nuclear receptor subfamily 1 group D members), ROR (retinoic acid-related orphan receptor), RORE (retinoic acid-related orphan receptor response element), FGFR (fibroblast growth factor receptor), CYP7A1 (cholesterol-7α-hydroxylase/cytochrome P450 7A1), FXR (farnesoid X receptor), SHP (small heterodimer partner), KO (knockout), KLF15 (Kruppel-like factor 15), WAT (white adipose tissue), FFA(free fatty acid), PPARα (peroxisome proliferator-activated receptor α), E4BP4 (E4 promoter-binding protein 4), PTH (parathyroid hormone), iFGF23 (intact FGF23), cFGF23 (C-terminal FGF23), CKD (chronic kidney disease), TRF (timerestricted feeding), non-alcoholic steatohepatitis (NASH)

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Section: Circadian Disruption and Endocrine Fgf Dysregulationmentioning

confidence: 95%

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

Yang,

Zarbl,

Guo

2024

Mol Pharmacol

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“…To minimize the impact of variable factors on the results, researchers have turned to animal models. Experimental studies on mice with diet-induced obesity have confirmed an association between female obesity and reproductive disorders in the peri-conception period [5][6][7][8][9][10]. However, some of these studies produced inconsistent results as well.…”

Section: Introductionmentioning

confidence: 99%

Overweight and Fertility: What We Can Learn from an Intergenerational Mouse Obesity Model

Fabian

Kubandová-Babeľová

Kšiňanová

et al. 2022

IJERPH

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The aim of this study was to evaluate the effects of being overweight on the ability to conceive, fertilization rate, and in vivo development of embryos in regularly cycling, spontaneously ovulating, and naturally mated female mice. The study was based on statistical analysis of data collected during 14 experiments with identical design, performed on 319 control and 327 obese mice, developed in an intergenerational model of obesity induction which eliminates the impact of aging and high-fat feeding. Six-week-old mice with a vaginal sperm plug were slaughtered on embryonic days 2, 3, or 4, and the flushed contents of the oviducts and uteri were assessed by stereomicroscopy. The results showed no association between being overweight and the proportion of ovulating or fertilized females. On the other hand, a strong association was found between being overweight and ovulation yield. On embryonic day 2, significantly higher numbers of eggs were recovered from the oviducts of fertilized obese mice. Maternal overweight status was also associated with higher developmental capacities of preimplantation embryos. In conclusion, contrary to studies based on the high-fat-diet model, in female mice fed regular chow, being overweight was associated with an increased ovulation quota and higher developmental rate of fertilized oocytes. Being overweight did not impact ability to conceive. On the other hand, as documented in our previous studies, the quality of oocytes and blastocysts recovered from overweight mice developed in an intergenerational model of obesity was low.

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Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality

Kankanam Gamage,

Hashimoto,

Miyamoto

et al. 2024

J Assist Reprod Genet

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Effects of time-restricted feeding and type of food on fertility competence in female mice

Cited by 5 publications

References 65 publications

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

Overweight and Fertility: What We Can Learn from an Intergenerational Mouse Obesity Model

Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality

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