Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

Abstract

ABBREVIATIONSFGF (fibroblast growth factor), BA (bile acid), SCN (suprachiasmatic nucleus), CG (clock gene), CCG (clock-controlled gene), BMAL1(brain and muscle Arnt-Like 1), CLOCK (circadian locomotor output cycles kaput), PER (period), CRY (cryptochrome), REV-ERB (nuclear receptor subfamily 1 group D members), ROR (retinoic acid-related orphan receptor), RORE (retinoic acid-related orphan receptor response element), FGFR (fibroblast growth factor receptor), CYP7A1 (cholesterol-7α-hydroxylase/cytochrome P450 7A1), FXR (farnesoid X receptor), SHP (small heterodimer partner), KO (knockout), KLF15 (Kruppel-like factor 15), WAT (white adipose tissue), FFA(free fatty acid), PPARα (peroxisome proliferator-activated receptor α), E4BP4 (E4 promoter-binding protein 4), PTH (parathyroid hormone), iFGF23 (intact FGF23), cFGF23 (C-terminal FGF23), CKD (chronic kidney disease), TRF (timerestricted feeding), non-alcoholic steatohepatitis (NASH)