Effects of Tiam 1 on Invasive Capacity of Gastric Cancer Cells in vitro and Underlying Mechanisms

Zhu, Jinming; Yu, Ping

doi:10.7314/apjcp.2013.14.1.201

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Recent research report that α5β1-integrin plays an important role in stimulating endothelial cell proliferation at an early step in the angiogenic process (Li et al, 2012). Secondly, α5β1-integrin may partake in activating MMP-2 Morozevich et al, 2009;Shi et al, 2011;Kesanakurti et al, 2012;Zhu et al, 2013). Invasion and metastasis of cancer have a close relationship with basement membrane adhesion and extracellular matrix degradation.…”

Section: Relationship Between α5β1-integrin and Overall Survival Of Cmentioning

confidence: 99%

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

Wang¹,

Chen²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Asian Pacific J Cancer Prev, 14 (6), 3891-3895 IntroductionCervical cancer (CC) is the second most common malignant diseases of women in the world. More than 500,000 new cases of cervical cancer were reported each year worldwide, of which approximately 1/3 from China mainland. So, cervical cancer is a cause of significant morbidity and cancer-related mortality in China women. With the improvement of modern irradiation techniques and development of novel drugs, cervical cancer remains an unsolved problem of oncology both due to the increased rate of local failures and of the distant metastasis. Although the death rate for cervical cancer has decreased dramatically since the introduction of cervical cytology as a widespread screening procedure, the survival rate at advanced stages of disease has not improved. Therefore, characterization of identifiable molecular markers may play an important role in understanding of molecular pathogenesis and in identifying latently prognostic biomarkers for cervical cancer.Numerous studies demonstrated that α5β1-integrin expression levels are altered in many types of cancer (Morozevich et al., 2009), there may be involved in modulating effect on several signalling pathways ,which are closely related to the regulation of cell survival, proliferation ,differentiation and apoptosis, and in stimulating tumor angiogenesis (Zeng et al., 2009) Although it has been shown that α5β1-integrin AbstractThe purpose of this study was to evaluate the association of expression of α5β1-integrin with clinicopathologic features and prognosis in cervical cancer. Levels of α5β1-integrin in normal cervical mucosa and cervical cancer tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. α5β1-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05). Positive expression rates of α5β1-integrin in patients with poor histologic differentiation, lymph node metastasis, and recurrence were elevated. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expression of α5β1-integrin revealed a highly significant difference in human cervical cancer cases (P < 0.05), suggesting that overexpression of α5β1-integrin is associated with a worse prognosis.The α5β1-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical cancer. The current study indicated that α5β1-integrin may be an independent prognostic factor for cervical cancer patients.

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Section: Relationship Between α5β1-integrin and Overall Survival Of Cmentioning

confidence: 99%

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

Wang¹,

Chen²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Furthermore, the Tiam1-Rac signaling axis is able to cross-talk with other signaling pathways, such as the c-Jun N-terminal kinase (p38 MAPK) pathway and the extracellular signal-regulated kinase pathway [16, 17], which may implicate the Tiam1-Rac pathway in the regulation of gene transcription. Additionally, several studies reported the role of Tiam1 in the promotion of malignant transformation, tumor proliferation, invasion and metastasis [18–23]. Moreover, Tiam1 has been reported to participate in the regulation of the tumor microenvironment [24] by promoting the formation of E-cadherin-mediated cell-cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological implications of Tiam1 overexpression in invasive ductal carcinoma of the breast

Liu

Piao

et al. 2016

BMC Cancer

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BackgroundT-lymphoma invasion and metastasis-inducing protein 1 (Tiam1) has been implicated in tumor occurrence and progression. Recent studies have shown that high expression levels of Tiam1 protein appear to be associated with the progression of numerous human tumors. This study attempted to explore the role of Tiam1 protein in tumor progression and the prognostic evaluation of breast cancer.MethodsThe localization of the Tiam1 protein was determined in the MDA-MB-231 breast cancer cell line using immunofluorescence (IF) staining. In addition, a total of 283 breast tissue samples, including 153 breast cancer tissues, 67 ductal carcinoma in situ (DCIS) and 63 adjacent non-tumor breast tissues, were analyzed by immunohistochemical (IHC) staining of the Tiam1 protein. The correlation between Tiam1 expression and clinicopathological characteristics was evaluated by Chi-square test and Fisher’s exact tests. Disease-free survival (DFS) and 10-year overall survival (OS) rates were calculated by the Kaplan-Meier method. Additionally, univariate and multivariate analyses were performed by the Cox proportional hazards regression models.ResultsTiam1 protein showed a mainly cytoplasmic staining pattern in breast cancer cells; however, nuclear staining was also observed. Tiam1 protein expression was significantly higher in breast cancers (42.5 %, 65/153) and DCIS (40.3 %, 27/67) than in adjacent non-tumor tissues (12.7 %, 8/63). In addition, Tiam1 associated with tumor stage and Ki-67 expression, but negatively correlated with receptor tyrosine-protein kinase erbB-2 (Her2) expression. Moreover, survival analyses showed that DFS and 10-year OS rates were significantly lower in breast cancer patients with high Tiam1 expression than those with low Tiam1 expression. Univariate analysis suggested that molecular types, clinical stage, Her2 expression levels and Tiam1 expression levels were also significantly associated with DFS and 10-year OS rates of breast cancer patients. Furthermore, multivariate analysis suggested that Tiam1 expression is a significant independent prognostic factor along with tumor stage in patients with breast cancer.ConclusionsTiam1 expression is frequently up-regulated in breast cancer. Tiam1 expression correlated with clinicopathological parameters, suggesting that it may be a useful prognostic biomarker and potential therapeutic target for patients with breast cancer.

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“…The expression of CD29 is related to the migration and the invasion ability of tumor cells in tumor tissues. However, in peripheral blood lymphocytes, CD29 is usually expressed on the surface of the activated memory T cells (Leitner et al, 2010;Zhu et al, 2013;Song et al, 2014;Zhan et al, 2014). The percentage of CD29 + cells accounts for (87.91±11.66)% in EAAL cells, which means the strong adhesion ability of EAAL cells.…”

Section: Discussionmentioning

confidence: 99%

Adoptive Immunotherapy for Small Cell Lung Cancer by Expanded Activated Autologous Lymphocytes: a Retrospective Clinical Analysis

Zhang

Li²,

Sun³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To investigate the clinical efficacy of expanded activated autologous lymphocytes (EAAL) in patients with small cell lung cancer (SCLC). Materials and Methods: A total of 32 SCLC patients were selected and randomly divided into EAAL treatment and control groups, 16 cases in each. EAAL were obtained by proliferation of peripheral blood mononuclear cells (PBMCs) of patients followed by phenotype determination. Clinical data of all patients were recorded. Patients of both groups were followed up and the overall survival (OS) were compared retrospectively. Results: After culture and proliferation in vitro, the percentages of CD3 + , CD3 + CD8 + , CD45RO + , CD28 + , CD29 + , CD8 + CD28 + and CD3+CD16+/CD56+ cells increased markedly (p<0.05). The OS of the EAAL treatment group was longer than that of control group, but the difference was not statistically significant (p=0.060, HR=0.487, 95%CI 0.228~1.037). 1-to 3-year survival rates in EAAL treatment group were longer than those in control group, but there was still no significant difference (p>0.05). COX multivariate regression analysis showed that the number of chemotherapy cycles and the application of EAAL immunotherapy were independent prognostic factors for SCLC patients. The OS in females and chemotherapy≤6 cycles were obviously prolonged after EAAL immunotherapy. Conclusions: In vitro induction and proliferation of EAAL is easy and biologically safe. Generally, EAAL adoptive immunotherapy can evidently prolong the OS of SCLC patients.

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Effects of Tiam 1 on Invasive Capacity of Gastric Cancer Cells in vitro and Underlying Mechanisms

Cited by 5 publications

References 26 publications

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

Clinicopathological implications of Tiam1 overexpression in invasive ductal carcinoma of the breast

Adoptive Immunotherapy for Small Cell Lung Cancer by Expanded Activated Autologous Lymphocytes: a Retrospective Clinical Analysis

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