Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers

Sofuoglu, Mehmet; Mouratidis, Maria; Yoo, Sonah; Culligan, Kerry; Kosten, Thomas R.

doi:10.1007/s00213-005-0010-y

Cited by 38 publications

(33 citation statements)

References 45 publications

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“…Our prior work demonstrated that these doses produced robust physiological and subjective responses in male and female smokers (Sofuoglu et al, 2006). The injections were given 30 min apart, which allowed subjective and cardiovascular responses to return to baseline levels (Sofuoglu et al, 2005;Sofuoglu et al, 2006;Sofuoglu et al, 2009). An escalating dosing schedule rather than counterbalanced dosing was chosen to prevent any carryover effects from the preceding nicotine dose to saline and to increase the safety of the study by exposing subjects first to saline, followed by a low dose of nicotine before a higher dose was administered.…”

Section: Methodsmentioning

confidence: 99%

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Sofuoglu

Herman

Nadim

et al. 2012

Neuropsychopharmacol

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102

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The ratio of nicotine metabolites (trans-3 0 -hydroxycotinine (3HC) to cotinine) correlates with nicotine clearance. In previous studies, high nicotine metabolite ratio (NMR) predicted poor outcomes for smoking cessation treatment with nicotine patch. The underlying mechanisms that associate NMR with treatment outcomes have not been fully elucidated. A total of 100 smokers were divided into quartiles based on their baseline plasma NMR. Following overnight abstinence, smokers received saline followed by escalating intravenous doses of nicotine (0.5 and 1.0 mg/70 kg) given 30 min apart. The effects of nicotine on subjective, plasma cortisol, heart rate, and systolic and diastolic blood pressure measures were obtained. Smokers in the first NMR quartile (slower metabolizers) had lower Fagerstrom Test for Nicotine Dependence (FTND) scores, suggesting lower levels of dependence. In contrast, smokers in the fourth NMR quartile (faster metabolizers) reported greater craving for cigarettes following overnight abstinence from smoking and reported greater ratings of nicotine-induced good drug effects, drug liking, and wanting more drug. Higher NMR was also associated with greater heart rate increases in response to nicotine. These results suggest that enhanced nicotine reward and cigarette craving may contribute to the poor treatment response in smokers with high NMR. These findings warrant further investigation, especially in treatment-seeking smokers undergoing cessation treatment.

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Section: Methodsmentioning

confidence: 99%

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Sofuoglu

Herman

Nadim

et al. 2012

Neuropsychopharmacol

Self Cite

102

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“…GABAbased therapies have been explored for numerous addictive disorders (eg, Brebner et al, 2002;Brodie et al, 2003;Franklin et al, 2009;Kampman et al, 2004;Kaplan et al, 2003) and have been found to reduce cigarette consumption (Franklin et al, 2009) and cigarette craving (Sofuoglu et al, 2005). Preclinically, GABAergic drugs improve drug-induced cognitive disruptions (Arai et al, 2009;Porrino et al, 2012) and reduce responding to nicotine cues (Paterson et al, 2005).…”

Section: Figurementioning

confidence: 97%

GABA Levels in The Dorsal Anterior Cingulate Cortex Associated with Difficulty Ignoring Smoking-Related Cues in Tobacco-Dependent Volunteers

Janes

Jensen

Farmer

et al. 2013

Neuropsychopharmacol

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Substance abusers have difficulty ignoring drug-related cues, which is associated with relapse vulnerability. This 'attentional bias' towards drug cues translates into an inability to ignore drug-related stimuli and may reflect deficits in the brain regions, such as the dorsal anterior cingulate cortex (dACC)-a key region in cognitive control and adaptive decision making. Quantifying relationships between attentional biases to drug cues and dACC neurochemistry could aid in identifying neurobiological mechanisms associated with increased relapse vulnerability precipitated by drug cues. As gamma-aminobutyric acid (GABA) deficits have been linked to impaired cognition and addictive disorders, we hypothesized that reduced GABA in the dACC would be associated with increased attentional biases towards smoking-related cues. We confirmed this hypothesis among nicotine-dependent tobacco smokers by combining an offline behavioral measure of attentional bias with magnetic resonance spectroscopy. Smokers with the greatest attentional bias also experienced more negative affect during early nicotine withdrawal. Findings revealed a relationship between heightened reactivity to drug cues, and both decreasing dACC GABA and early withdrawal symptoms. Because reduced GABA function in frontal brain regions disrupt cognitive function, our findings suggest that smokers with diminished dACC GABA may lack the cognitive resources to successfully ignore highly salient distractors such as tobacco-related stimuli and therefore might be more prone to cue-induced relapse. This newly discovered relationship between dACC GABA and attentional bias provides evidence for a neurochemical target, which may aid smoking cessation in highly cue-reactive individuals.

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“…Similarly, modafinil (a non-amphetamine stimulant) improved working memory in treatment-seeking methamphetamine users with poor baseline working memory scores (Kalechstein, De La Garza, and Newton, 2010). Lastly, the anticonvulsant tiagabine improved performance on the Stroop test in recently abstinent smokers (Sofuoglu et al, 2005).…”

Section: Cognitive Enhancersmentioning

confidence: 99%

Executive Dysfunction in Addiction

Jarmolowicz¹,

Mueller²,

Koffarnus³

et al. 2013

The Wiley‐Blackwell Handbook of Addiction Psychopharmacology

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Effects of tiagabine in combination with intravenous nicotine in overnight abstinent smokers

Abstract: These results suggest that GABA enhancing medication tiagabine may reduce the rewarding effects of nicotine and improve cognitive performance in abstinent smokers. The utility of GABA medications for smoking cessation needs to be examined further in controlled clinical trials.

Cited by 38 publications

References 45 publications

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

GABA Levels in The Dorsal Anterior Cingulate Cortex Associated with Difficulty Ignoring Smoking-Related Cues in Tobacco-Dependent Volunteers

Executive Dysfunction in Addiction

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