2022
DOI: 10.1590/s2175-97902022e19847
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Effects of thymoquinone in a rat model of reserpine-induced depression

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Cited by 4 publications
(6 citation statements)
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“…The effect on body weight loss is well established and can serve as a predictor of the degree of "reserpinization" (Halaris and Freedman, 1975). Along with the current study, chronic reserpine administration under different administration schemes have reported induced body weight loss in rats (Kuzay et al, 2022;Sethy and Hodges Jr., 1985). However, contradictory outcomes have also been shown (Ikram and Haleem, 2017).…”
Section: Reserpine Effects On Physiology and Well-beingsupporting
confidence: 59%
“…The effect on body weight loss is well established and can serve as a predictor of the degree of "reserpinization" (Halaris and Freedman, 1975). Along with the current study, chronic reserpine administration under different administration schemes have reported induced body weight loss in rats (Kuzay et al, 2022;Sethy and Hodges Jr., 1985). However, contradictory outcomes have also been shown (Ikram and Haleem, 2017).…”
Section: Reserpine Effects On Physiology and Well-beingsupporting
confidence: 59%
“…While FST is understood to evaluate behavioral despair, which may be related to concepts of learned helplessness [71], these should not be considered unconditionally when employed as a lone measure of affective function. Additional data for depression-like behaviors were identified with the Tail Suspension Test (TST) paradigm [49,51,58,66], although results failing to find these effects were also highlighted [72]. Results from Sucrose Preference Test (SPT) and Novelty Suppressed Feeding Test (NSFT) assays remained consistent, such that the model reliably produced depression-like behaviors in animals as elucidated in these assessments [37,53,56,63,66,67,73].…”
Section: Reserpine Evaluationmentioning
confidence: 98%
“…Additional data for depression-like behaviors were identified with the Tail Suspension Test (TST) paradigm [49,51,58,66], although results failing to find these effects were also highlighted [72]. Results from Sucrose Preference Test (SPT) and Novelty Suppressed Feeding Test (NSFT) assays remained consistent, such that the model reliably produced depression-like behaviors in animals as elucidated in these assessments [37,53,56,63,66,67,73]. Further investigation into depression-like behavior using the splash test yielded mixed results, with one study reporting reduced grooming behaviors [56], while others did not [53,64].…”
Section: Reserpine Evaluationmentioning
confidence: 99%
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