Effects of through-hole drug reservoirs on key clinical attributes for drug-eluting depot stent

Hsiao, Hao‐Ming; Chiu, Yi-Hsiang; Wu, Tsung-Yuan; Shen, Jung-Keng; Lee, Ting-Yu

doi:10.1016/j.medengphy.2012.08.021

Cited by 20 publications

(13 citation statements)

References 20 publications

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“…The modification of these stents brought both its own advantages and disadvantages the same as all previous stent technologies. They have improved the duration of drug release from the stent although they have failed in mechanical integrity required for stent backbone in most cases (Hsiao et al 2013 ). Polymer-free stents also indicated a capability for long-term safety in comparison to traditional coated DES (Farah 2018 ).…”

Section: More New Stent Systemsmentioning

confidence: 99%

Cardiovascular stents: overview, evolution, and next generation

et al. 2018

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Compared to bare-metal stents (BMSs), drug-eluting stents (DESs) have been regarded as a revolutionary change in coronary artery diseases (CADs). Releasing pharmaceutical agents from the stent surface was a promising progress in the realm of cardiovascular stents. Despite supreme advantages over BMSs, in-stent restenosis (ISR) and long-term safety of DESs are still deemed ongoing concerns over clinically application of DESs. The failure of DESs for long-term clinical use is associated with following factors including permanent polymeric coating materials, metallic stent platforms, non-optimal drug releasing condition, and factors that have recently been supposed as contributory factors such as degradation products of polymers, metal ions due to erosion and degradation of metals and their alloys utilizing in some stents as metal frameworks. Discovering the direct relation between stent materials and associating adverse effects is a complicated process, and yet it has not been resolved. For clinical success it is of significant importance to optimize DES design and explore novel strategies to overcome all problems including inflammatory response, delay endothelialization, and sub-acute stent thrombosis (ST) simultaneously. In this work, scientific reports are reviewed particularly focusing on recent advancements in DES design which covers both potential improvements of existing and recently novel prototype stent fabrications. Covering a wide range of information from the BMSs to recent advancement, this study mostly sheds light on DES’s concepts, namely stent composition, drug release mechanism, and coating techniques. This review further reports different forms of DES including fully biodegradable DESs, shape-memory ones, and polymer-free DESs.

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Section: More New Stent Systemsmentioning

confidence: 99%

Cardiovascular stents: overview, evolution, and next generation

et al. 2018

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“…The literature review shows that this type of modification of stents has brought many advantageous features. The duration of drug release from the stent has been improved, although the mechanical integrity required for the stent backbone has been problematic in most cases [ 159 ]. However, it is worth noting that their long-term safety distinguishes polymer-free stents compared to traditional DES-coated stents [ 15 ].…”

Section: New Stent Systemsmentioning

confidence: 99%

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Rykowska

Nowak

Nowak³

2020

Molecules

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Controlled drug delivery is a matter of interest to numerous scientists from various domains, as well as an essential issue for society as a whole. In the treatment of many diseases, it is crucial to control the dosing of a drug for a long time and thus maintain its optimal concentration in the tissue. Heart diseases are particularly important in this aspect. One such disease is an obstructive arterial disease affecting millions of people around the world. In recent years, stents and balloon catheters have reached a significant position in the treatment of this condition. Balloon catheters are also successfully used to manage tear ducts, paranasal sinuses, or salivary glands disorders. Modern technology is continually striving to improve the results of previous generations of stents and balloon catheters by refining their design, structure, and constituent materials. These advances result in the development of both successive models of drug-eluting stents (DES) and drug-eluting balloons (DEB). This paper presents milestones in the development of DES and DEB, which are a significant option in the treatment of coronary artery diseases. This report reviews the works related to achievements in construction designs and materials, as well as preparation technologies, of DES and DEB. Special attention was paid to the polymeric biodegradable materials used in the production of the above-mentioned devices. Information was also collected on the various methods of producing drug release coatings and their effectiveness in releasing the active substance.

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“…For instance: 1) in the shell, soluble porogenic additives (such poly(ethylene glycol) or poly(vinylpyrrolidone)) could be used to regulate the drug release behavior, as is currently the case in some particle-based drug depots [59]; 2) the approach could be extended to achieve the sustained release of soluble drugs (a major challenge in pharmaceutics); 3) drug delivery systems with more complicated drug release profiles could be achieved, e.g. multiple-phase release of a drug using a pure drug exterior compartment; 4) combined therapies with temporally sequential drug release characteristics could be explored; 5) an extremely wide range of un-spinnable fluids including dilute polymer solutions [60], surfactant or electrolyte solutions could be explored as the outer fluid in modified tri-axial processes, in order to create numerous nanoscale biomaterials with complicated nanostructures.…”

Section: Figmentioning

confidence: 99%

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Yang

et al. 2017

Acta Biomaterialia

120

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Nanosized sustainedrelease drug depots fabricated using modified tri-axial electrospinning, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.01.069 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning Abstract:Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 µm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

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Effects of through-hole drug reservoirs on key clinical attributes for drug-eluting depot stent

Cited by 20 publications

References 20 publications

Cardiovascular stents: overview, evolution, and next generation

Cardiovascular stents: overview, evolution, and next generation

Drug-Eluting Stents and Balloons—Materials, Structure Designs, and Coating Techniques: A Review

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

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