Effects of three divalent cations: manganese, zinc, and magnesium on arterial blood pressures in guinea pigs

Abstract

TurkeyOur aim was to compare the effects of the divalent cations, namely magnesium, zinc, and manganese on the arterial blood pressures and heart rate of guinea pigs. Eighteen guinea pigs weighing 500À700 g were divided into three groups (six in each group), and three divalent cations as sulfate salt (MgSO 4 , ZnSO 4 , MnSO 4 ) were administered to all animals after 20-min period of stabilization and at three escalating concentrations (10 )6 , 10, 10 )4 mol/kg intravenously, respectively) in 25-min intervals. Each animal received only one kind of cation. Arterial pressures and heart rate were measured and their derivatives were calculated (dp/dt). Our study showed that divalent cations lowered the arterial blood pressures. No significant differences were between groups for systolic, diastolic, and mean pressures, except that 10 )4 mol/kg ZnSO 4 was lethal. The heart rates values of ZnSO 4 (202 ± 9) was significantly (P < 0.05) lower after 10 )6 mol/kg than MgSO 4 (230 ± 7). Three divalent cations caused to decrease on arterial pressures. Zn 2+ caused cardiac arrest in the highest dose. Intravenous administration of Mn 2+ and Mg 2+ seems to have similar effects on arterial blood pressures and heart rate. Further work is needed to relate effects on Mn 2+ for their possible use in the emergency department.