Effects of three different embryonic exposure modes of 2, 2′, 4, 4′-tetrabromodiphenyl ether on the path angle and social activity of zebrafish larvae

Zhang, Bin; Chen, Xiaoling; Pan, Ruijie; Xu, Ting; Zhao, Jing; Huang, Wenping; Liu, Youyu; Yin, Daqiang

doi:10.1016/j.chemosphere.2016.11.098

Cited by 30 publications

(8 citation statements)

References 28 publications

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“…When exposed to low doses of either of two prominent PBDEs, BDE-99 and BDE-47, zebrafish exposed to BDE-99 but not BDE-47 exhibited reduced social preference behavior (Glazer et al, 2018b). Another study reported elevated shoaling between pairs of zebrafish larvae following embryonic BDE-47 treatment (Zhang et al, 2017). Interestingly, the same group also tested two BDE-47 metabolites, 6-OH-BDE-47 and 6-MeO-BDE-47, using the same experimental setup, and found that 6-MeO-BDE-47 but not 6-OH-BDE-47 inhibited shoaling (Zhang et al, 2018).…”

Section: Disease-relevant Social-deficit Models In Zebrafishmentioning

confidence: 99%

The zebrafish subcortical social brain as a model for studying social behavior disorders

Geng

Peterson

2019

Disease Models &Amp; Mechanisms

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Social behaviors are essential for the survival and reproduction of social species. Many, if not most, neuropsychiatric disorders in humans are either associated with underlying social deficits or are accompanied by social dysfunctions. Traditionally, rodent models have been used to model these behavioral impairments. However, rodent assays are often difficult to scale up and adapt to high-throughput formats, which severely limits their use for systems-level science. In recent years, an increasing number of studies have used zebrafish (Danio rerio) as a model system to study social behavior. These studies have demonstrated clear potential in overcoming some of the limitations of rodent models. In this Review, we explore the evolutionary conservation of a subcortical social brain between teleosts and mammals as the biological basis for using zebrafish to model human social behavior disorders, while summarizing relevant experimental tools and assays. We then discuss the recent advances gleaned from zebrafish social behavior assays, the applications of these assays to studying related disorders, and the opportunities and challenges that lie ahead.

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Section: Disease-relevant Social-deficit Models In Zebrafishmentioning

confidence: 99%

The zebrafish subcortical social brain as a model for studying social behavior disorders

Geng

Peterson

2019

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

show abstract

“…Neurobehavioral tests were performed on a ZebraBox platform (ViewPoint, France) according to our previous methods [20,21], which can realize automatic tracking and high-throughput screening of larvae. Locomotion, path angle, and two-fish social activity of the same batch of exposed larvae were adopted to evaluate the neurobehavioral effects induced by BDE-209 at 5, 6, and 7 dpf, respectively, with light stimulus.…”

Section: Neurobehavioral Test Protocolmentioning

confidence: 99%

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

Zhang

Yin

et al. 2020

Environ Sci Eur

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Background: Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies of BDE-209 focused on the health effects and toxicity of thyroid disruption, oxidative stress, neurotoxicity, and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209.Results: BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf ) larvae; however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concentration exposures. Conclusion:The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.

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“…Neurobehavioral tests were performed on a ZebraBox platform (ViewPoint, France) according to our previous methods [20,21], which can realize automatic tracking and high-throughput screening of larvae. Locomotion, path angle, and two-fish social activity of the same batch of larvae were adopted to evaluate the neurobehavioral effects induced by BDE-209 on exposed larvae at 5, 6, and 7 dpf respectively with light stimulus.…”

Section: Neurobehavioral Test Protocolmentioning

confidence: 99%

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study

Zhang

Yin

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Although listed in the Stockholm Convention, commercial Decabromodiphenyl ether (c-DecaBDE) is still being produced in many factories and used as a kind of flame retardants primarily in plastic polymers and textiles. Widespread use offered many exposure ways of its major ingredient, BDE-209, to humans and the environment. Most current studies of BDE-209 focused on the health effects and toxicity of thyroid disruption, oxidative stress, neurotoxicity and reproductive function, but seldom spread light on the relationship between neurobehavioral toxicity and visual dysfunction. Using zebrafish larvae model, we hope to uncover the potential relationship between the neurobehavioral and visual effects after exposure to BDE-209. Results: BDE-209 exposure could not induce the changes of locomotion and path angle in 5 days post fertilization (dpf) larvae, however, 5 μg/L BDE-209 exposure caused locomotor hyperactivity and more responsive turns at 7 dpf. The social activity of 50 μg/L exposure group was significantly higher than the control group at 6 dpf. Besides, 5 and 50 μg/L exposure caused the upregulation and downregulation of four cone opsin genes, respectively. The expression of rhodopsin gene was not influenced by both concentration exposures. Conclusion: The neurobehavioral effects induced by 5 μg/L BDE-209 exposure were consistent with the upregulation of four cone opsins in 7 dpf larvae. The low concentration of BDE-209 exposure caused the hyperactivity and more responsive turns of larvae possibly contributing to the disruption on the cone opsin expressions of larvae. Our results would provide the mechanism cue of neurobehavioral toxicity after BDE-209 exposure and call for more attention on the ecotoxicology studies of BDE-209.

show abstract

Effects of three different embryonic exposure modes of 2, 2′, 4, 4′-tetrabromodiphenyl ether on the path angle and social activity of zebrafish larvae

Cited by 30 publications

References 28 publications

The zebrafish subcortical social brain as a model for studying social behavior disorders

The zebrafish subcortical social brain as a model for studying social behavior disorders

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: a pilot study

The potential relationship between neurobehavioral toxicity and visual dysfunction of BDE-209 on zebrafish larvae: A pilot study

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