Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury

Sencar, Leman; Çoşkun, Gülfidan; Şaker, Dilek; Sapmaz, Tuğçe; Kara, Samet; Çelenk, Alper; Polat, Sema; Yılmaz, Derviş; Dağlıoğlu, Yusuf Kenan; Polat, Sait

doi:10.1080/01913123.2021.1923600

Cited by 11 publications

(11 citation statements)

References 36 publications

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“…The findings of this study reported that Theranekron decreased axonal and myelin damage after sciatic nerve injury and increased the neuroprotective effect. [ 9 ] In a recent study, Sencar et al[ 7 ] reported that the combination therapy of Theranekron and alphalipoic acid supported structural recovery and could be considered as an effective treatment protocol following peripheral nerve injury. In another recent study, Theranekron, as an apoptosis-inducing agent, was possibly shown to be an excellent alternative therapeutic drug for the treatment of malignant neoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is used as an anti-inflammatory and anti-edematous agent in many infectious diseases, as well as in traumatic and necrotic diseases. [ 6 , 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…In addition, it is used as an anti-inflammatory and anti-edematous agent in many infectious diseases, as well as in traumatic and necrotic diseases. [6,7] Many studies have been conducted with Theranekron in rat models. In these studies, it has been reported that the compound accelerates wound healing, [8] reduces axonal and myelin damage after sciatic nerve damage, and has a neuroprotective effect.…”

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confidence: 99%

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The effect of Theranekron on femur fracture healing in an experimental rat model

Güven

Özkan²,

Türközü³

et al. 2022

Jt Dis Relat Surg

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Objectives The aim of this study was to investigate the radiological, biomechanical, histopathological and immunohistochemical effects of Theranekron on fracture healing in an experimental rat model. Materials and methods Forty-eight male albino Wistar rats were used. Four groups were formed, with 12 rats in each of Theranekron groups 1 and 2, and control groups 1 and 2. After a fracture was created in the right femur of the rats included in the study, fixation was performed with an intramedullary Kirschner wire. Theranekron was administered subcutaneously to Theranekron groups 1 and 2 at a dose of 0.3 mg/kg on days 0, 5 and 10. After radiographic analysis of the femurs of Theranekron group 1 and control group 1 rats at four weeks of the study was performed, both groups were divided into two equal subgroups (six femurs in each group). Histopathological and immunohistochemical examinations were performed in one subgroup and biomechanical examination in the other subgroup. At the end of six weeks, the rats in Theranekron group 2 and control group 2 were evaluated after applying the same procedure as in the fourth week. Results When the mean radiological scores of the Theranekron and control groups were compared, a statistically significant difference was found in favor of the Theranekron group at four and six weeks (p=0.028 and p=0.006, respectively). At four weeks, statistically significant higher biomechanical forces were obtained in the Theranekron group compared to the control group (p=0.030). In the histopathological evaluation, the inflammation value of the control group at four weeks was statistically significantly higher than the Theranekron group (p=0.027). The angiogenesis, osteoblast proliferation, and bone formation values of the Theranekron group were significantly higher than the control group (p=0.014, p=0.014, and p=0.005, respectively). At six weeks, the bone formation values of the Theranekron group were statistically significantly higher than the control group (p=0.021). The difference between the Theranekron group and the control group scores of the immunohistochemical evaluation were statistically significantly different at four and six weeks (p=0.006 and p=0.011, respectively). Conclusion Theranekron may play a role in accelerating fracture healing by reducing acute inflammation process in the early period of fracture union, increasing fracture strength, angiogenesis, osteoblast proliferation, and bone formation.

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Section: Discussionmentioning

confidence: 99%

“…In addition, it is used as an anti-inflammatory and anti-edematous agent in many infectious diseases, as well as in traumatic and necrotic diseases. [ 6 , 7 ]…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of Theranekron on femur fracture healing in an experimental rat model

Güven

Özkan²,

Türközü³

et al. 2022

Jt Dis Relat Surg

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“…TRN has a supportive effect in the treatment of inflammation and necrotic processes (7). It also has anti-edema effects (8). It has been reported that breast trauma and eczema are also successfully treated with TRN (8).…”

Section: Introductionmentioning

confidence: 99%

“…It also has anti-edema effects (8). It has been reported that breast trauma and eczema are also successfully treated with TRN (8). Doxorubicin (Dox), which is an anthracycline class antineoplastic, is an antibiotic with strong cytotoxicity and a topoisomerase-II enzyme inhibitor that is frequently prescribed in cancer treatment (9).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Teranecrone and Doxorubicin on Human Colorectal Adenocarcinoma (CaCo-2) Cell Line

Taspınar

Ertugrul

2022

Ege Tıp Bilimleri Dergisi

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OBJECTİVE: In this study, it was aimed to evaluate the antineoplastic efficacy of Teranecron, which is frequently used in veterinary medicine, on human colorectal adenocarcinoma. MATERİALS AND METHODS: Teranecron (TRN) was used to evaluate its effectiveness in the study, and the antineoplastic drug Doxorubicin was used as a positive control. The cytotoxic activity of Teranecron on the human colorectal cell line CaCo-2 was investigated. MTT proliferation test was used to determine the viability rates. ANOVA Tukey test was used for statistical analysis and the level of significance was accepted as P

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“Theranekron: A Novel Anti-inflammatory Candidate for Acetic Acid-Induced Colonic Inflammation in Rats”

et al. 2022

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Effects of Theranekron and alpha-lipoic acid combined treatment on GAP-43 and Krox-20 gene expressions and inflammation markers in peripheral nerve injury

Cited by 11 publications

References 36 publications

The effect of Theranekron on femur fracture healing in an experimental rat model

The effect of Theranekron on femur fracture healing in an experimental rat model

Cytotoxic Effect of Teranecrone and Doxorubicin on Human Colorectal Adenocarcinoma (CaCo-2) Cell Line

“Theranekron: A Novel Anti-inflammatory Candidate for Acetic Acid-Induced Colonic Inflammation in Rats”

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