Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages

Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro

“…5B). These concentrations were much lower than effective concentrations reported for polyphenols, such as quercetin (100 µM), required to inhibit iNOS gene expression in a similar experimental design (Wadsworth & Koop, 1999). Additionally, MC at 100 µg/mL (Fig.…”

Heat Shock Protein 70 Is a Potential Virulence Factor in MurineToxoplasmaInfection Via Immunomodulation of Host NF-κB and Nitric Oxide

“…A potential limitation of the protocols used in this study to inhibit HSP70 expression by T. gondii (i.e., the combination of transient transfection with antisense oligonucleotides and quercetin) is that quercetin and other related flavonoids are known to induce multiple changes in the cells exposed to them (32)(33)(34)(35). The complex nature of the relationship between flavonoid compounds such as quercetin, heat shock proteins, and the immune response obviously requires further characterization, but it should be emphasized that, in this study, only parasites were treated with quercetin; the host cells that were used to examine the effects of parasite HSP70 on various parameters of the immune response were not exposed directly to quercetin at any time.…”

Metabolite profile and in vitro activities of Phagnalon saxatile (L.) Cass. relevant to treatment of Alzheimer’s disease

“…Recently, the effects of selected polyphenolics on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells have been reported. These studies have shown that some polyphenolics or methanol extracts of plants inhibit NO production [4][5][6][7] . Most clinically important medicines belong to steroidal or non-steroidal anti-inflammatory chemical therapeutics for treatment of inflammation-related diseases.…”