Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial

Abstract

Our results suggest that epicatechin may in part contribute to the cardioprotective effects of cocoa and tea by improving insulin resistance. It is unlikely that quercetin plays an important role in the cardioprotective effects of tea. This study was registered at clinicaltrials.gov as NCT01691404.

Assessing the effects of a short-term green tea intervention in skin microvascular function and oxygen tension in older and younger adults

“…It works through counteracting the actions of contracting factors, including angiotensin-11 and endothelin-1. Various studies have isolated specific components of GT and observed an augmentation of NO status (Loke et al 2008). Similarly, oral administration of catechins increased NO levels and also decreased enodthelin-1 concentrations (a vasoconstrictor) (Persson et al 2006).…”

Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target

“…Quercetin has been demonstrated to be equally or more effective than resveratrol in attenuating the TNF levels [221]. The safety, tolerability and efficacy of resveratrol, genistein, sylimarin and quercetin has also been proven in multiple randomized, double-blind, placebo controlled clinical studies [218][219][220][222][223][224][225][226]. In addition, many flavonoids have also been reported to possess antibacterial, antifungal and antiviral properties etc., however, these properties cannot be generalized to entire category of flavonoids, yet, may give an advantage over current anti-TNF agents [227,228].…”

Marker Compound of Jati Belanda (Guazuma ulmifolia Lamk) Extract as Anti-Cholesterol

“…Terkait dengan penurun kolesterol, kuersetin dilaporkan memiliki efek kardioprotektif (Dower et al 2015), menurunkan risiko arterosklerosis (Sun et al 2015), dan meningkatkan efluks kolesterol pada liver serta meningkatkan perubahan kolesterol menjadi asam empedu (Zhang et al 2016). Berdasarkan laporan kemampuan kuersetin sebagai penurun kolesterol tersebut, kuersetin dapat digunakan sebagai senyawa penciri kualitas daun jati belanda sebagai penurun kolesterol.…”