Marker Compound of Jati Belanda (Guazuma ulmifolia Lamk) Extract as Anti-Cholesterol

Batubara, Irmanida; Husnawati, Husnawati; Darusman, Latifah Kosim; Mitsunaga, Tohru

doi:10.18343/jipi.22.2.87

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Di Lombok Timur dibeberapa wilayah, jarak kepyar tumbuh liar dan menjadi tanaman yang dianggap sebagai gulma yang mengganggu, sehingga masyarakat menebang dan membuangnya, padahal ternyata tanaman tersebut memiliki banyak manfaat dalam pengobatan (Al-Mamun et al, 2016). Tumbuhan ini mengandung flavonoid kuhusnya kuersetin, glikosida, saponin, tanin, alkaloid, kaempferol dan steroid yang dipercaya memiliki banyak manfaat dalam pengobatan salah satunya penyakit kardiovaskular (Nishizawa, 2020); (Widyaningrum, 2015); (Batubara et al, 2017).…”

Section: Pendahuluanunclassified

Efektivitas Infusa Daun Jarak Kepyar (Ricinus communis L.) terhadap Kadar Kolesterol Total dan HDL Serum Darah Tikus Galur Wistar

Hikmah¹,

Hariadi²,

Sovia³

2022

sinteza

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Jarak kepyar (Ricinus communis L.) adalah salah satu tanaman herbal yang mengandung flavonoid khususnya kuersetin, tanin, dan saponin dimana senyawa-senyawa ini dipercaya dapat memberikan efek antihiperlipidemia. Tujuan dari penelitian ini untuk mengetahui efektivitas infusa dan untuk mendapatkan konsentrasi infusa daun jarak kepyar yang paling efektif sebagai antihiperlipidemia pada tikus galur wistar. Penelitian ini merupakan jenis penelitian true exsperimental dengan rancangan pretest-postest kelompok. Hewan uji terbagi menjadi 5 kelompok yaitu kontrol positif (simvastatin), kontrol negatif dan perlakuan (infusa daun jarak kepyar) dengan konsentrasi 10%, 20% dan 30% dengan masing-masing kelompok sebanyak 5 ekor. Sebelum perlakuan hewan uji diberikan induksi kuning telur selama 25 hari kemudian diukur kadar kolesterol total, trigliserida, dan HDL. Pengukuran dilakukan sebelum dan sesudah induksi kuning telur kemudian dilakukan kembali setelah infusa daun jarak kepyar diberikan. Parameter yang diukur adalah kadar kolesterol total, trigliserida dan HDL. Berdasarkan hasil pengukuran kadar setelah pemberian infusa daun jarak kepyar diperoleh hasil persentasi penurunan kolesterol total yaitu kontrol negatif (8.43%), kontrol positif (15.28%), konsentrasi 10% (10.23%), konsentrasi 20% (20.03%), dan kelompok konsentrasi 30% (27.13%) dan peningkatan HDL yaitu kelompok kontrol negatif (1.23%), kontrol positif (9.23%), konsentrasi 10% (2.96%), konsentrasi 20% (7.85%), dan kelompok konsentrasi 30% (5.14%). Konsentrasi 20% dan 30% memberikan penururunan kadar kolesterol total secara signifikan (p<0.05) dan peningkatan kadar HDL secara signifikan (p<0.05) oleh kontrol 20% jika dibandingkan dengan kontrol negatif. Infusa daun jarak kepyar (Ricinus communis L.) konsentrasi 30% paling efektif menurunkan kadar kolesterol total dan trigliserida, sedangkan yang paling efektif untuk meningkatkan kadar HDL adalah konsentrasi 20%.

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Section: Pendahuluanunclassified

Efektivitas Infusa Daun Jarak Kepyar (Ricinus communis L.) terhadap Kadar Kolesterol Total dan HDL Serum Darah Tikus Galur Wistar

Hikmah¹,

Hariadi²,

Sovia³

2022

sinteza

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“…In guazuma leaves, the potential compounds associated with antioxidant and anti-triglyceride activity included flavonoid, tannins, carotenoid and phenolic acids [19]. Batubara [20] successfully fractionated quercetin in guazuma leaf extracts which could reduce cholesterol level.…”

Section: Antioxidant Activity Of Guazuma Leavesmentioning

confidence: 99%

Antioxidant Activity of Ethanol Extract from Guazuma ulmifolia Lamk. Leaves in Modulating Apoptosis of Yeast Cells (Saccharomyces cerevisiae)

2018

PFEBM-18,LMEHSS-18 August 8-10, 2018 Pnom Penh (Cambodia)

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“…Research conducted by (Ulfah & Iskandar, 2020), revealed that the aqueous extract of Dutch teak leaves at a dose of 50 mg/Kg BW was able to significantly inhibit the increase in total and LDL cholesterol levels in the control group. Quercetin in Dutch teak leaf extract owns a fairly high level and is efficacious in lowering cholesterol levels (Batubara et al, 2017). Supriani's research et al (2019), uncovered a change in cholesterol levels after administering Dutch teak leaf tea in Kedungsari Hamlet, Balongsari Megaluh Village.…”

Section: Introductionmentioning

confidence: 99%

The Administration of Dutch Teak Leaf Tea Extract (Guazama Ulmifolia lamk) in Reducing Cholesterol Levels in Depo Acceptors

et al. 2022

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Depo hormonal contraceptives are significantly effective contraceptives with a low failure rate. Women who apply this contraceptive may experience several side effects on fat metabolism, which is an increase and decrease in total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C). The objective of this study was to identify the influence of Dutch teak leaves (Guazuma Ulmifolia Lamk) on the cholesterol levels in the Depo acceptors. Quasi-experiment research design with one group pretest posttest design model. The pretest was completed first by the total number of samples which is 60 respondents. Furthermore, 250 ml of Dutch teak tea is consumed every morning and evening after eating. The intervention lasted two weeks, followed by a retest (posttest). Dutch tea pre and post results were analyzed employing t-test statistics on variable body weight (p = 0.706), systolic blood pressure (p = 0.322), and cholesterol (p = 0.001), and the Wilcoxon test on diastolic pressure variables (p = 0.043) and triglycerides (p = 0.417). With a p-value of 0.001, it demonstrates that there is a significant difference in cholesterol levels after being treated with Dutch teak tea. With a p-value greater than 0.05, there was no difference in triglycerides, weight, or blood pressure after receiving Dutch teak tea treatment. An increase in cholesterol levels is one of the side effects of DMPA acceptors. Therefore, consuming Dutch teak leaves is an alternative treatment option.

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Marker Compound of Jati Belanda (Guazuma ulmifolia Lamk) Extract as Anti-Cholesterol

Abstract: ABSTRAK Daun jati belanda (Guazuma ulmifoliaLamk

Cited by 4 publications

References 9 publications

Efektivitas Infusa Daun Jarak Kepyar (Ricinus communis L.) terhadap Kadar Kolesterol Total dan HDL Serum Darah Tikus Galur Wistar

Efektivitas Infusa Daun Jarak Kepyar (Ricinus communis L.) terhadap Kadar Kolesterol Total dan HDL Serum Darah Tikus Galur Wistar

Antioxidant Activity of Ethanol Extract from Guazuma ulmifolia Lamk. Leaves in Modulating Apoptosis of Yeast Cells (Saccharomyces cerevisiae)

The Administration of Dutch Teak Leaf Tea Extract (Guazama Ulmifolia lamk) in Reducing Cholesterol Levels in Depo Acceptors

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