Effects of the Pulse Polarity on Helium Plasma Jets: Discharge Characteristics, Key Reactive Species, and Inactivation of Myeloma Cell

Liu, Zhijie; Xu, Dehui; Zhou, Chao; Cui, Qingjie; He, Tongtong; Chen, Ze‐Yu; Liu, Dingxin; Chen, Hailan; Kong, Michael G.

doi:10.1007/s11090-018-9920-4

Cited by 23 publications

(13 citation statements)

References 60 publications

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“…In this field, plasma cytotoxic potential of cancer cells and its selective effect has been received great attention recently. It has been found that radical oxygen species (ROS) and radical nitrogen species (RNS) created by CAP interaction with air are hypothesized to intervene the effects observed in the biological system [13,14]. These reactive species are known to be employed in interaction with proteins and lipids [15].…”

Section: Introductionmentioning

confidence: 99%

Improving Cold Atmospheric Pressure Plasma Efficacy on Breast Cancer Cells Control-Ability and Mortality Using Vitamin C and Static Magnetic Field

Mehrabifard

Mehdian

Hajisharifi

et al. 2019

Plasma Chem Plasma Process

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Since the last decades, there have been numerous reports about the interaction of magnetic field (MF) and cold atmospheric plasma (CAP) with the biological systems, separately. In this manuscript, we have investigated the combined effect of CAP with the static magnetic field (SMF) as an effective method for cancer cells treatment. MDA-MB-231 breast cancer cells were cultured and treated with CAP in different input power and different exposure time in the presence and absence of the SMF. Vitamin C is used in medium, and cell viability is investigated in the presence and absence of this antioxidant compound. The MTT assay has been employed to measure cell survival, and then T-test and one-way ANOVA are used to assess the significance level of quantitative data. In order to determine the migration rate of cancer cells, wound healing assay has been carried out. Results show that presence of the SMF and vitamin C as well as increasing the input power has a significant role on the attenuation of the survival and migration rate of the cells. The results of the present investigation will greatly contribute to improve the CAP efficiency in cancer therapy through using the SMF and vitamin C as a complement to conventional CAP therapies.

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Section: Introductionmentioning

confidence: 99%

Improving Cold Atmospheric Pressure Plasma Efficacy on Breast Cancer Cells Control-Ability and Mortality Using Vitamin C and Static Magnetic Field

Mehrabifard

Mehdian

Hajisharifi

et al. 2019

Plasma Chem Plasma Process

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“…OH by reaction (10). In acidic environment, the reaction ( 11) is considered to be a primary pathway to generate ONOO − /ONOOH [6,17,25]. For the production of O .…”

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confidence: 99%

The impact of surface-to-volume ratio on the plasma activated water characteristics and its anticancer effect

Liu¹,

Wang²,

Pang³

et al. 2021

J. Phys. D: Appl. Phys.

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Plasma activated water (PAW), as a green and potential technology, plays a significant role in bio-medicine applications. Surface-to-volume ratio of treated liquid during the preparation of PAW seriously affects the PAW chemistry characteristics, and ultimately results in different biological effects. However, that how does the surface-to-volume ratio affect PAW characteristics and anticancer effect induced by PAW is unclear. In this work, the surface-to-volume ratio is regulated to investigate the dynamic variation of chemical characteristics and cell apoptosis. Results display physicochemical properties including pH, ORP, and liquid temperature are varied with nonlinear trend besides conductivity. While the levels of RONS containing NO2 −, NO3 −, H+ are changed with linear trend except H2O2 ONOO− and O . 2 −. Furthermore, increasing surface-to-volume ratio could effectively accelerate cell apoptosis, enhance intracellular ROS concentration and strengthen anticancer effects. Thus, it is concluded that tuning surface to volume ratio can effectively enhance the reactive species flux into the liquid that leads to remarkable anticancer activity of PAW rather than the surface-to-volume ratio that is directly responsible for the enhanced impact on the cells. Additionally, the possible apoptosis mechanisms linked with RONS are also discussed. Clarifying the relationship between the surface-to-volume ratio and the PAW characteristics is beneficial to much insights into the chemistry nature of PAW and tailoring biological effect caused by PAW.

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“…Hydroxide radicals serve as the main contributor to the formation of gaseous H 2 O 2 via reaction OH + OH → H 2 O 2 and the dissolution of gaseous H 2 O 2 is a vital pathway of the formation of aqueous H 2 O 2 . [ 38 ] Aqueous H 2 O 2 is not only a precursor to ONOO – but also presents strong oxidative that could cause the destruction of cell components in bacteria. [ 25 ]…”

Section: Resultsmentioning

confidence: 99%

“…Figure 2d depicts that the emission intensities of N 2 (C → B) in natural air or synthetic air were ordered as follows when the discharge power was 3. [38] Aqueous H 2 O 2 is not only a precursor to ONOObut also presents strong oxidative that could cause the destruction of cell components in bacteria. [25] 3.3 | Aqueous reactive species in the PAS…”

Section: Optical Characteristics Of Surface Plasmasmentioning

confidence: 99%

Bactericidal effects of plasma‐activated saline prepared by surface dielectric barrier discharge with different dielectric layers and working gases

Huang

Guo

Zhao

et al. 2022

Plasma Processes & Polymers

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The polytetrafluoroethylene (PTFE) serves as a dielectric layer for surface dielectric barrier discharge (SDBD) and the prepared plasma‐activated saline (PAS) exhibited strong bactericidal effects, however, the fluorides are inevitably generated and bring about side effects in biological application. In this study, the SDBD devices with the dielectric layers of quartz or ceramic compared with that with PTFE were utilized to explore the effective and fluoride‐free PAS using different working gases. The Quartz‐PAS prepared with air exhibited a relatively strong bactericidal effect without inducing the DNA‐protein crosslinks (DPCs) in Escherichia coli cells, while the Ceramic‐PAS exhibited a weak bactericidal effect and induced the DPCs formation. This study supplies guidance in the preparation and regulation of PAS for biomedical applications.

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Effects of the Pulse Polarity on Helium Plasma Jets: Discharge Characteristics, Key Reactive Species, and Inactivation of Myeloma Cell

Cited by 23 publications

References 60 publications

Improving Cold Atmospheric Pressure Plasma Efficacy on Breast Cancer Cells Control-Ability and Mortality Using Vitamin C and Static Magnetic Field

Improving Cold Atmospheric Pressure Plasma Efficacy on Breast Cancer Cells Control-Ability and Mortality Using Vitamin C and Static Magnetic Field

The impact of surface-to-volume ratio on the plasma activated water characteristics and its anticancer effect

Bactericidal effects of plasma‐activated saline prepared by surface dielectric barrier discharge with different dielectric layers and working gases

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