Effects of the pesticide amitraz and its metabolite BTS 27271 on insulin and glucagon secretion from the perfused rat pancreas: involvement of α2D-Adrenergic receptors

Amitraz poisoning, an emerging problem: epidemiology, clinical features, management, and preventive strategies

“…4 It is probably due to the petroleum distillates mixed with amitraz in commercial preparations 1 4 Convulsion Neurotoxic and proconvulsant effects are triggered by α 2 receptors partially 18 Polyuria α 2 adrenoceptor stimulation decreases antidiuretic hormone (ADH) and renin secretion, inhibition of ADH effect, and enhanced diuresis by increased glomerular filtration rate 43 Gastrointestinal hypomotility α 2 adrenoceptor stimulation causes hypomotility 46 47 Hyperglycaemia α 2 adrenoceptor stimulation reduces insulin secretion and causes hyperglycaemia. 36 The animal study conducted by Abu-Basha and colleagues 48 showed that amitraz inhibited insulin and stimulated glucagon secretion from the perfused rat pancreas, and inhibited insulin secretion no history of cardiac disease who recovered completely in 24 hours. We did not observe any changes in ECG in our cases.…”

Acute Amitraz Poisoning in Adults: Clinical Features, Laboratory Findings, and Management

“…The hyperglycemia in our patients persisted for a short time and resolved spontaneously. Abu-Basha et al reported that amitraz and its active metabolite, BTS 27271, inhibited insulin and stimulated glucagon secretion from the perfused rat pancreas in a concentration-dependent manner (23). Clinically, this effect is quite short-lived and does not lead to any clinical sequelae (22).…”

Uso tópico do amitraz em concentração terapêutica em gatos

“…Apesar dessa diferença, os valores estavam dentro do intervalo considerado normal para a espécie (73 -134 mg dL -1 ) (KANEKO et al, 1997). O mecanismo provável de ação do amitraz e de seu metabólito ativo BTS 27271 na indução da hiperglicemia ocorre por meio da inibição de secreção de insulina, que é mediada por receptores α 2 -adrenégicos, mais especificamente pelo subtipo α 2D localizado nas ilhotas pancreáticas (ABU-BASHA et al, 1999).…”