Effects of the penetration of a root canal filling material into the mandibular canal. I. Tissue reaction to the material

Kawakami, Toshiyuki; Nakamura, Chihito; Eda, Shigeo

doi:10.1111/j.1600-9657.1991.tb00180.x

Cited by 23 publications

(15 citation statements)

References 12 publications

(19 reference statements)

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“…In an experimental study on dog and monkey teeth, Sealapex was found to encourage apical closure by cementum deposition compared with Kerr Root Canal Sealer (SybronEndo/Kerr) when the root filling was 1 mm short of radiographic apex (47). Vitapex introduced into the mandibular canal of dogs caused heterotopic calcification and ossification within the area of penetration (48). Others found no significant differences in periapical tissue responses between Sealapex, CRCS, and a ZOE-based sealer in dog teeth (33).…”

Section: The Effect Of Calcium Hydroxide On Periapical Tissue Healingmentioning

confidence: 96%

Calcium Hydroxide–Based Root Canal Sealers: A Review

Desai

Chandler

2009

Journal of Endodontics

179

132

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Section: The Effect Of Calcium Hydroxide On Periapical Tissue Healingmentioning

confidence: 96%

Calcium Hydroxide–Based Root Canal Sealers: A Review

Desai

Chandler

2009

Journal of Endodontics

179

132

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“…Kawakami et al did histopathological studies regarding tissue reactions to calcium hydroxide-based root canal filling material [5][6][7][8] . We also previously reported and discussed in detail the tissue damage and its fate in vivo [9][10][11][12] . The data presented by Kawakami et al in 2012 were published as a monographs 12) .…”

Section: Discussionmentioning

confidence: 99%

Mouse Subcutaneous Tissue Reaction to Calcium Hydroxide-based Root Canal Filling Material

Shoumura

Matsuda

Osuga

et al. 2014

J. Hard Tissue Biology.

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Mouse subcutaneous tissue reaction to an embedded calcium hydroxide-based root canal filling material was analyzed histopathologically. After the material was placed within the mouse dorsal subcutaneous tissues, we performed examinations using histopathological, histochemical and immunohistochemical techniques. Two weeks after embedment, the proliferation of granulation tissue had already begun to surround the calcification. Most of the cells observed were macrophages. Likewise, multinucleated giant cells increased significantly. The multinucleated giant cells were observed as two types. In one, the centers of the giant cells were vacuoles, while in the others there were deeply stained calcifications with hematoxylin. Twelve weeks after embedment of the materials, further growth of multinucleated giants cells were sighted. Histochemically, von Kossa-stainpositive granules were observed within the macrophages and multinucleated giant cells as black fine granules. According to the TRAP stained specimens, the multinucleated giant cells especially reacted strongly at 4 weeks. However, the reaction became very weak at 12 weeks. CD68 immunohistochemical staining showed positive reactions in the cytoplasm of the proliferating macrophages and multinucleated giant cells. These results suggest that multinucleated giant cells are present in the surrounding tissues due to implantation of the calcium hydroxidebased root canal filling material, and that the presence of ACP in the cells is due to ingested calcium during active phagocytosis, which would disappear later on.

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“…[10,11,12] Calcium Hydroxide from the pulpecotmy material can also cause heterotopic calcifications in the body tissues. [13] With regards to all these aspects, this combination of material may not ideal and safe.…”

Section: Discussionmentioning

confidence: 99%