Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

Abutarboush, Rania; Aligbe, Chioma; Pappas, Georgina; Saha, Banani; Arnaud, Françoise; Haque, Ashraful; Auker, Charles R.; McCarron, Richard M.; Scultetus, Anke; Moon-Massat, Paula F.

doi:10.3390/jfb5040246

Cited by 10 publications

(9 citation statements)

References 27 publications

(29 reference statements)

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“…HR was significantly different among the groups at baseline (T0) but was still within the normal range for rats under the anesthesia regimen used in this study [13,14,15,16,17] and did not exhibit any cumulative change (comparing T0 to T150) over time within any of the groups (Table 1). The only significant change in HR after an individual infusion was a slight transient increase in the 0.9% NaCl group after the third infusion.…”

Section: Resultsmentioning

confidence: 73%

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Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Abutarboush

Saha

Mullah

et al. 2016

JFB

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Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend.

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Section: Resultsmentioning

confidence: 73%

“…A cranial window was prepared as previously described [13,14,17]. Briefly, pial microvasculature was accessed through a rectangular craniotomy prepared in the right parietal bone.…”

Section: Methodsmentioning

confidence: 99%

Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Abutarboush

Saha

Mullah

et al. 2016

JFB

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“…27 Therefore, we examined the relationship between vessel diameter/size and responsiveness to the vasoactive mediators evaluated in this study by grouping vessels into size categories, as previously described. 30,31,37 Responses of small (<50 μ m) and medium (50–100 μ m) sized vessels were compared across the different time points examined in this study. Overall, in sham animals, the three vasoactive mediators used in this study elicited responses that were consistent with the previously established normal vascular reactivity induced by these agents (Fig.…”

Section: Resultsmentioning

confidence: 99%

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

Abutarboush

Kawoos

et al. 2019

Journal of Neurotrauma

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Exposure to blast overpressure may result in cerebrovascular impairment, including cerebral vasospasm. The mechanisms contributing to this vascular response are unclear. The aim of this study was to evaluate the relationship between blast and functional alterations of the cerebral microcirculation and to investigate potential underlying changes in vascular microstructure. Cerebrovascular responses were assessed in sham- and blast-exposed male rats at multiple time points from 2 h through 28 days after a single 130-kPa (18.9-psi) exposure. Pial microcirculation was assessed through a cranial window created in the parietal bone of anesthetized rats. Pial arteriolar reactivity was evaluated in vivo using hypercapnia, barium chloride, and serotonin. We found that exposure to blast leads to impairment of arteriolar reactivity >24 h after blast exposure, suggesting delayed injury mechanisms that are not simply attributed to direct mechanical deformation. Observed vascular impairment included a reduction in hypercapnia-induced vasodilation, increase in barium-induced constriction, and reversal of the serotonin effect from constriction to dilation. A reduction in vascular smooth muscle contractile proteins consistent with vascular wall proliferation was observed, as well as delayed reduction in nitric oxide synthase and increase in endothelin-1 B receptors, mainly in astrocytes. Collectively, the data show that exposure to blast results in delayed and prolonged alterations in cerebrovascular reactivity that are associated with changes in the microarchitecture of the vessel wall and astrocytes. These changes may contribute to long-term pathologies involving dysfunction of the neurovascular unit, including cerebral vasospasm.

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“…Finally, OxyVita C (OXYVITA Inc., New Windsor, NY), a large molecular weight tetrameric bovine Hb polymer, has been evaluated in a healthy rat model to determine its effect on cerebral microcirculation. Infusion of OxyVita C was found to not cause vasoconstriction in cerebral pial arterioles (Abutarboush et al 2014).…”

Section: Introductionmentioning

confidence: 84%

The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

Zhao

Chen

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The effects of polymerized porcine hemoglobin (pPolyHb) on hemodynamic stability and maintenance of mesenteric microvascular function were explored in a rat model of hemorrhagic shock (HS). Following controlled hemorrhage, rats were infused with equal volumes of either pPolyHb, hetastarch (HES), or red blood cell (RBC). The results showed that pPolyHb was superior to HES and RBC in restoring hemodynamic stability and reversing anaerobic metabolism. We observed a reduction in the diameter of mesenteric microvasculature after HS. Resuscitation with pPolyHb and RBC was able to restore the diameters of the venules and arterioles, whereas HES failed to restore the diameters during the observation period.

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Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

Cited by 10 publications

References 27 publications

Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

Exposure to Blast Overpressure Impairs Cerebral Microvascular Responses and Alters Vascular and Astrocytic Structure

The effect of pPolyHb on hemodynamic stability and mesenteric microcirculation in a rat model of hemorrhagic shock

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